A Novel Electroencephalographic Evaluation of Noxious Stimulation During Isoflurane Anesthesia in Dogs

Overview

Journal Exp Anim

Date 2024 Aug 7

PMID 39111850

Authors

Wei-Mao Hung

Hsien-Chi Wang

Julia Chu-Ning Hsu

Affiliations

Soon will be listed here.

Abstract

In veterinary clinical medicine, evaluating the balance between nociception and antinociception presents a great challenge for anesthesiologists during canine surgeries. Heart rate (HR) and mean arterial pressure (MAP) are suitable indexes for monitoring noxious stimuli during anesthesia. Frontal electroencephalography (EEG) records, including processed parameters, are recommended for evaluating nociceptive balance in anesthetized unconscious human patients, which is unexplored in veterinary medicine. Therefore, the objective is to explore the response of processed EEG parameters to noxious stimulation and elucidate the impact of noxious stimulation on frontal cortical activity in dogs anesthetized with 1.5% isoflurane. Fourteen dogs were included and underwent frontal EEG monitoring, measuring the patient state index (PSI) and spectral edge frequency (SEF) before and after administering noxious stimulation using the towel clamp method on the tail of each 1.5% isoflurane-anesthetized dog. As the noxious stimulation was applied, there was a simultaneous increase in PSI, HR, and MAP, with PSI exhibiting a drastic response. SEF, especially on the left side, also increased with noxious stimulation. In EEG power spectral analysis, the delta band was decreased, and the alpha and beta bands showed an increase following noxious stimulation, with a more profound elevation of beta band on the left side. This study suggests that noxious stimulation brings asymmetric frontal cortical arousal, changing brain activity by suppressing delta wave and augmenting alpha and beta waves. Consequently, PSI seems to be a potential indicator for detecting stimuli in canine isoflurane anesthesia.

References

Soehle M, Kuech M, Grube M, Wirz S, Kreuer S, Hoeft A . Patient state index vs bispectral index as measures of the electroencephalographic effects of propofol. Br J Anaesth. 2010; 105(2):172-8. DOI: 10.1093/bja/aeq155. View

Andics A, Gabor A, Gacsi M, Farago T, Szabo D, Miklosi A . Neural mechanisms for lexical processing in dogs. Science. 2016; 353(6303):1030-1032. DOI: 10.1126/science.aaf3777. View

de Beer N, Van Hooff J, Cluitmans P, Korsten H, Grouls R . Haemodynamic responses to incision and sternotomy in relation to the auditory evoked potential and spontaneous EEG. Br J Anaesth. 1996; 76(5):685-93. DOI: 10.1093/bja/76.5.685. View

Coste C, Guignard B, Menigaux C, Chauvin M . Nitrous oxide prevents movement during orotracheal intubation without affecting BIS value. Anesth Analg. 2000; 91(1):130-5. DOI: 10.1097/00000539-200007000-00024. View

Soehle M, Ellerkmann R, Grube M, Kuech M, Wirz S, Hoeft A . Comparison between bispectral index and patient state index as measures of the electroencephalographic effects of sevoflurane. Anesthesiology. 2008; 109(5):799-805. DOI: 10.1097/ALN.0b013e3181895fd0. View

Kemp B, Olivan J . European data format 'plus' (EDF+), an EDF alike standard format for the exchange of physiological data. Clin Neurophysiol. 2003; 114(9):1755-61. DOI: 10.1016/s1388-2457(03)00123-8. View

Ricci Z, Robino C, Rufini P, Cumbo S, Cavallini S, Gobbi L . Monitoring anesthesia depth with patient state index during pediatric surgery. Paediatr Anaesth. 2023; 33(10):855-861. DOI: 10.1111/pan.14711. View

Kox W, von Heymann C, Heinze J, Prichep L, Roy John E, Rundshagen I . Electroencephalographic mapping during routine clinical practice: cortical arousal during tracheal intubation?. Anesth Analg. 2006; 102(3):825-31. DOI: 10.1213/01.ane.0000197776.26307.fa. View

Rowley P, Boncyk C, Gaskell A, Absalom A, Bonhomme V, Coburn M . What do people expect of general anaesthesia?. Br J Anaesth. 2017; 118(4):486-488. DOI: 10.1093/bja/aex040. View

10.

Karl S, Sladky R, Lamm C, Huber L . Neural Responses of Pet Dogs Witnessing Their Caregiver's Positive Interactions with a Conspecific: An fMRI Study. Cereb Cortex Commun. 2021; 2(3):tgab047. PMC: 8382916. DOI: 10.1093/texcom/tgab047. View

11.

Diesch T, Mellor D, Johnson C, Lentle R . Electroencephalographic responses to tail clamping in anaesthetized rat pups. Lab Anim. 2009; 43(3):224-31. DOI: 10.1258/la.2008.0080083. View

12.

Fahy B, Chau D . The Technology of Processed Electroencephalogram Monitoring Devices for Assessment of Depth of Anesthesia. Anesth Analg. 2017; 126(1):111-117. DOI: 10.1213/ANE.0000000000002331. View

13.

Mirra A, Casoni D, Barge P, Hight D, Levionnois O, Spadavecchia C . Usability of the SedLine® electroencephalographic monitor of depth of anaesthesia in pigs: a pilot study. J Clin Monit Comput. 2022; 36(6):1635-1646. PMC: 9637619. DOI: 10.1007/s10877-022-00807-3. View

14.

Prichep L, Gugino L, John E, Chabot R, Howard B, Merkin H . The Patient State Index as an indicator of the level of hypnosis under general anaesthesia. Br J Anaesth. 2004; 92(3):393-9. DOI: 10.1093/bja/aeh082. View

15.

Rogers L . Brain Lateralization and Cognitive Capacity. Animals (Basel). 2021; 11(7). PMC: 8300231. DOI: 10.3390/ani11071996. View

16.

Pellegrino F, Gomez Alvarez C . Electroencephalographic features of the developing brain in 72 dogs under xylazine sedation: a visual and statistical analysis. Front Vet Sci. 2023; 10:1150617. PMC: 10339384. DOI: 10.3389/fvets.2023.1150617. View

17.

Garland E . Pain processing in the human nervous system: a selective review of nociceptive and biobehavioral pathways. Prim Care. 2012; 39(3):561-71. PMC: 3438523. DOI: 10.1016/j.pop.2012.06.013. View

18.

Drover D, Ortega H . Patient state index. Best Pract Res Clin Anaesthesiol. 2006; 20(1):121-8. DOI: 10.1016/j.bpa.2005.07.008. View

19.

Bushnell M, ceko M, Low L . Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci. 2013; 14(7):502-11. PMC: 4465351. DOI: 10.1038/nrn3516. View

20.

Metzen D, Genc E, Getzmann S, Larra M, Wascher E, Ocklenburg S . Frontal and parietal EEG alpha asymmetry: a large-scale investigation of short-term reliability on distinct EEG systems. Brain Struct Funct. 2021; 227(2):725-740. PMC: 8843903. DOI: 10.1007/s00429-021-02399-1. View