Management and Outcomes of Breast Cancer Patients with Radiotherapy Interruption

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Aug 7

PMID 39109283

Authors

Fangrui Zhao

Dashuai Yang

Yanfang Lan

Xiangpan Li

Affiliations

Soon will be listed here.

Abstract

Background: Many cancer patients have not received timely treatment or even had treatment interruptions due to the COVID-19 pandemic. The objective of this investigation was to evaluate whether the prognosis of patients with breast cancer after surgery was affected by any interruptions in radiotherapy.

Methods: The healthcare documents for breast cancer patients experiencing radiotherapy interruption after surgery, including treatment-related characteristics, and time of interruption, type of disease progression, and survival status, were collected between January and April 2020 during the Wuhan blockade.

Results: The final number of patients included was 148, and neither the Kaplan-Meier (KM) survival curve nor the cross-tabulation analysis found statistical significance. Cox regression analysis also did not identify risk factors associated with PFS.

Conclusions: The prognosis of patients with postoperative breast cancer may not be significantly impacted by the interruption of radiotherapy, given its integration with additional treatments like targeted and endocrine therapies.

References

Hermens A, Barendsen G . Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after x-irradiation. Eur J Cancer (1965). 1969; 5(2):173-89. DOI: 10.1016/0014-2964(69)90065-6. View

Trayes K, Cokenakes S . Breast Cancer Treatment. Am Fam Physician. 2021; 104(2):171-178. View

Giuliano A, Hunt K, Ballman K, Beitsch P, Whitworth P, Blumencranz P . Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA. 2011; 305(6):569-75. PMC: 5389857. DOI: 10.1001/jama.2011.90. View

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

Gandhi M, Yokoe D, Havlir D . Asymptomatic Transmission, the Achilles' Heel of Current Strategies to Control Covid-19. N Engl J Med. 2020; 382(22):2158-2160. PMC: 7200054. DOI: 10.1056/NEJMe2009758. View

Rutqvist L . Adjuvant endocrine therapy. Best Pract Res Clin Endocrinol Metab. 2003; 18(1):81-95. DOI: 10.1016/s1521-690x(03)00046-0. View

Marta G, Hijal T, Carvalho H . Reirradiation for locally recurrent breast cancer. Breast. 2017; 33:159-165. DOI: 10.1016/j.breast.2017.03.008. View

Shah C, Al-Hilli Z, Vicini F . Advances in Breast Cancer Radiotherapy: Implications for Current and Future Practice. JCO Oncol Pract. 2021; 17(12):697-706. DOI: 10.1200/OP.21.00635. View

Liang W, Guan W, Chen R, Wang W, Li J, Xu K . Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020; 21(3):335-337. PMC: 7159000. DOI: 10.1016/S1470-2045(20)30096-6. View

10.

Howlader N, Altekruse S, Li C, Chen V, Clarke C, Ries L . US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst. 2014; 106(5). PMC: 4580552. DOI: 10.1093/jnci/dju055. View

11.

Azria D, Belkacemi Y, Romieu G, Gourgou S, Gutowski M, Zaman K . Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HO-RT): a phase 2 randomised trial. Lancet Oncol. 2010; 11(3):258-65. DOI: 10.1016/S1470-2045(10)70013-9. View

12.

Ishitobi M, Shiba M, Nakayama T, Motomura K, Koyama H, Nishiyama K . Treatment sequence of aromatase inhibitors and radiotherapy and long-term outcomes of breast cancer patients. Anticancer Res. 2014; 34(8):4311-4. View

13.

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y . Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020; 382(13):1199-1207. PMC: 7121484. DOI: 10.1056/NEJMoa2001316. View

14.

Golden E, Formenti S, Schiff P . Taxanes as radiosensitizers. Anticancer Drugs. 2013; 25(5):502-11. DOI: 10.1097/CAD.0000000000000055. View

15.

Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M . Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011; 378(9804):1707-16. PMC: 3254252. DOI: 10.1016/S0140-6736(11)61629-2. View

16.

Soerjomataram I, Bray F . Planning for tomorrow: global cancer incidence and the role of prevention 2020-2070. Nat Rev Clin Oncol. 2021; 18(10):663-672. DOI: 10.1038/s41571-021-00514-z. View

17.

Zhao F, Yang D, Li X . Effect of radiotherapy interruption on nasopharyngeal cancer. Front Oncol. 2023; 13:1114652. PMC: 10116059. DOI: 10.3389/fonc.2023.1114652. View

18.

LAIRD A . DYNAMICS OF TUMOUR GROWTH: COMPARISON OF GROWTH RATES AND EXTRAPOLATION OF GROWTH CURVE TO ONE CELL. Br J Cancer. 1965; 19:278-91. PMC: 2071357. DOI: 10.1038/bjc.1965.32. View

19.

Bese N, Hendry J, Jeremic B . Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation. Int J Radiat Oncol Biol Phys. 2007; 68(3):654-61. DOI: 10.1016/j.ijrobp.2007.03.010. View

20.

Fisher B, Anderson S, Bryant J, Margolese R, Deutsch M, Fisher E . Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002; 347(16):1233-41. DOI: 10.1056/NEJMoa022152. View