3D Printed Microneedles: Revamping Transdermal Drug Delivery Systems

Overview

Journal Drug Deliv Transl Res

Publisher Springer

Specialty Pharmacology

Date 2024 Aug 5

PMID 39103595

Authors

Ashlesh Prabhu

Vishal Baliga

Raghavendra Shenoy

Akanksha D Dessai

Usha Y Nayak

Affiliations

Soon will be listed here.

Abstract

One of the advancements of the transdermal drug delivery system (TDDS) is the development of microneedles (MNs). These micron-sized needles are used for delivering various types of drugs to address the disadvantage of other transdermal techniques as well as oral drug delivery systems. MNs have high patient acceptance due to self-administration with minimally invasive and pain compared to the parenteral drug delivery. Over the years, various methods have been adopted to evolve the MNs and make them more cost-effective, accurate, and suitable for multiple applications. One such method is the 3D printing of MNs. The development of MN platforms using 3D printing has been made possible by improved features like precision, printing resolution, and the feasibility of using low-cost raw materials. In this review, we have tried to explain various types of MNs, fabrication methods, materials used in the formulation of MNs, and the recent applications that utilize 3D-printed MNs.

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PMID: 39345034 PMC: 11583675. DOI: 10.1080/20415990.2024.2405456.

References

Boehm R, Miller P, Hayes S, Monteiro-Riviere N, Narayan R . Modification of microneedles using inkjet printing. AIP Adv. 2011; 1(2):22139. PMC: 3217292. DOI: 10.1063/1.3602461. View

Lim S, Ng J, Kang L . Three-dimensional printing of a microneedle array on personalized curved surfaces for dual-pronged treatment of trigger finger. Biofabrication. 2017; 9(1):015010. DOI: 10.1088/1758-5090/9/1/015010. View

Szeto B, Aksit A, Valentini C, Yu M, Werth E, Goeta S . Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs. Hear Res. 2020; 400:108141. PMC: 8656365. DOI: 10.1016/j.heares.2020.108141. View

Lei I, Jiang C, Lei C, de Rijk S, Tam Y, Swords C . 3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients. Nat Commun. 2021; 12(1):6260. PMC: 8556326. DOI: 10.1038/s41467-021-26491-6. View

Jung J, Jin S . Microneedle for transdermal drug delivery: current trends and fabrication. J Pharm Investig. 2021; 51(5):503-517. PMC: 7931162. DOI: 10.1007/s40005-021-00512-4. View

Jasim Uddin M, Scoutaris N, Economidou S, Giraud C, Chowdhry B, Donnelly R . 3D printed microneedles for anticancer therapy of skin tumours. Mater Sci Eng C Mater Biol Appl. 2019; 107:110248. DOI: 10.1016/j.msec.2019.110248. View

Chang H, Zheng M, Yu X, Than A, Seeni R, Kang R . A Swellable Microneedle Patch to Rapidly Extract Skin Interstitial Fluid for Timely Metabolic Analysis. Adv Mater. 2017; 29(37). DOI: 10.1002/adma.201702243. View

Khosraviboroujeni A, Mirdamadian S, Minaiyan M, Taheri A . Preparation and characterization of 3D printed PLA microneedle arrays for prolonged transdermal drug delivery of estradiol valerate. Drug Deliv Transl Res. 2021; 12(5):1195-1208. DOI: 10.1007/s13346-021-01006-4. View

Kadry H, Wadnap S, Xu C, Ahsan F . Digital light processing (DLP) 3D-printing technology and photoreactive polymers in fabrication of modified-release tablets. Eur J Pharm Sci. 2019; 135:60-67. DOI: 10.1016/j.ejps.2019.05.008. View

10.

Duarah S, Sharma M, Wen J . Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population. Eur J Pharm Biopharm. 2019; 136:48-69. DOI: 10.1016/j.ejpb.2019.01.005. View

11.

Ligon S, Liska R, Stampfl J, Gurr M, Mulhaupt R . Polymers for 3D Printing and Customized Additive Manufacturing. Chem Rev. 2017; 117(15):10212-10290. PMC: 5553103. DOI: 10.1021/acs.chemrev.7b00074. View

12.

Taylor R, Maharjan D, Moreu F, Baca J . Parametric study of 3D printed microneedle (MN) holders for interstitial fluid (ISF) extraction. Microsyst Technol. 2020; 26(6):2067-2073. PMC: 7238769. DOI: 10.1007/s00542-020-04758-0. View

13.

Dabbagh S, Sarabi M, Rahbarghazi R, Sokullu E, Yetisen A, Tasoglu S . 3D-printed microneedles in biomedical applications. iScience. 2021; 24(1):102012. PMC: 7814162. DOI: 10.1016/j.isci.2020.102012. View

14.

Chen X, Zhu L, Li R, Pang L, Zhu S, Ma J . Electroporation-enhanced transdermal drug delivery: Effects of logP, pK, solubility and penetration time. Eur J Pharm Sci. 2020; 151:105410. DOI: 10.1016/j.ejps.2020.105410. View

15.

Yao W, Li D, Zhao Y, Zhan Z, Jin G, Liang H . 3D Printed Multi-Functional Hydrogel Microneedles Based on High-Precision Digital Light Processing. Micromachines (Basel). 2019; 11(1). PMC: 7019295. DOI: 10.3390/mi11010017. View

16.

Balmert S, Donahue Carey C, Falo G, Sethi S, Erdos G, Korkmaz E . Dissolving undercut microneedle arrays for multicomponent cutaneous vaccination. J Control Release. 2019; 317:336-346. PMC: 8237702. DOI: 10.1016/j.jconrel.2019.11.023. View

17.

Yang Q, Zhong W, Xu L, Li H, Yan Q, She Y . Recent progress of 3D-printed microneedles for transdermal drug delivery. Int J Pharm. 2020; 593:120106. DOI: 10.1016/j.ijpharm.2020.120106. View

18.

Yadav V, Sharma P, Murty U, Mohan N, Thomas R, Dwivedy S . 3D printed hollow microneedles array using stereolithography for efficient transdermal delivery of rifampicin. Int J Pharm. 2021; 605:120815. DOI: 10.1016/j.ijpharm.2021.120815. View

19.

Yeung C, Chen S, King B, Lin H, King K, Akhtar F . A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery. Biomicrofluidics. 2019; 13(6):064125. PMC: 6906119. DOI: 10.1063/1.5127778. View

20.

Sultan R, Skrifvars M, Khalili P . 3D printing of polypropylene reinforced with hemp fibers: Mechanical, water absorption and morphological properties. Heliyon. 2024; 10(4):e26617. PMC: 10900766. DOI: 10.1016/j.heliyon.2024.e26617. View