Glycogen Phosphorylase Inhibitor Promotes Hair Growth Via Protecting from Oxidative-Stress and Regulating Glycogen Breakdown in Human Hair Follicles

Overview

Journal Biomol Ther (Seoul)

Specialty Pharmacology

Date 2024 Aug 5

PMID 39103246

Authors

Bomi Park

Daeun Kim

HaiRu Zhao

SoonRe Kim

Byung Cheol Park

SangHwa Lee

Yurim Lee

Hee Dong Park

Dongchul Lim

Sunyoung Ryu

Jae Sung Hwang

Affiliations

Soon will be listed here.

Abstract

Hair growth cycles are mainly regulated by human dermal papilla cells (hDPCs) and human outer root sheath cells (hORSCs). Protecting hDPCs from excessive oxidative stress and hORSCs from glycogen phosphorylase (PYGL) is crucial to maintaining the hair growth phase, anagen. In this study, we developed a new PYGL inhibitor, Hydroxytrimethylpyridinyl Methylindolecarboxamide (HTPI) and assessed its potential to prevent hair loss. HTPI reduced oxidative damage, preventing cell death and restored decreased level of anagen marker ALP and its related genes induced by hydrogen peroxide in hDPCs. Moreover, HTPI inhibited glycogen degradation and induced cell survival under glucose starvation in hORSCs. In ex-vivo culture, HTPI significantly enhanced hair growth compared to the control with minoxidil showing comparable results. Overall, these findings suggest that HTPI has significant potential as a therapeutic agent for the prevention and treatment of hair loss.

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