Synthesis of Quercetin Derivatives As Cytotoxic Against Breast Cancer MCF-7 Cell Line and Studies

Overview

Journal Future Med Chem

Specialties Chemistry
Pharmacy

Date 2024 Aug 5

PMID 39101595

Authors

Muhammad Rizwan Khan

Mohsin Abbas Khan

Irshad Ahmad

Javed Ahmed

Hammad Ahmed

Iqra Mubeen

Breena Awan

Farhat Ullah

Affiliations

Soon will be listed here.

Abstract

Quercetin being antioxidant and antiproliferative agent acts by inhibiting CDK2, with an increase in cancer prevalence there is a need to profile quercetin derivatives as CDK2 inhibitors. Schiff bases of quercetin were synthesized as cytotoxic agents against the MCF7 cell line. FTIR, H-NMR and C-NMR, CHNS/O analysis were employed along with and activities. 2q, 4q, 8q and 9q derivatives have maximum cytotoxic effect with IC values 39.7 ± 0.7, 36.65 ± 0.25, 35.49 ± 0.21 and 36.99 ± 0.45, respectively. Molecular docking also confirmed these results 8q has the highest binding potential of -9.165 KJ/mole making it a potent inhibitor of CDK2. These derivatives can be used as lead compounds as potent CDK2 inhibitors.

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