The Association of the Room Air Challenge with Long-term Outcomes in Extremely Preterm Infants

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2024 Aug 2

PMID 39095524

Authors

Samia Aleem

Barbara T Do

Marie G Gantz

Anna Maria Hibbs

Erik A Jensen

C Michael Cotten

William F Malcolm

Alan H Jobe

Rachel G Greenberg

Affiliations

Soon will be listed here.

Abstract

Objective: Evaluate the association between results of the room air (RA) challenge and death, respiratory morbidity, and neurodevelopmental impairment (NDI) at 2 years' corrected age.

Study Design: Cohort study of infants born <27 weeks' gestational age who underwent a RA challenge to determine BPD diagnosis at 36 weeks postmenstrual age.

Results: Of 1022 infants eligible for the RA challenge, 554 underwent testing and 223 passed. Test result was not associated with death or serious respiratory morbidities [adjusted relative risk (aRR) 1.01, 95% confidence interval (CI) 0.65-1.56] or death or moderate/severe NDI (aRR 1.06, 95% CI 0.81-1.39) at 2 years.

Conclusion: Results of the RA challenge were not associated with differences in respiratory or neurodevelopmental morbidity at 2 years, suggesting the RA challenge does not add prognostic value in contemporary extremely preterm infants.

Clinicaltrials:

Gov Id: Generic Database: NCT00063063.

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