Psychosocial Factors Linked to Uncontrolled Infection and Mortality Among People Living with HIV Who Use Substances: A Latent Class Analysis

Overview

Journal AIDS Behav

Specialty Infectious Diseases

Date 2024 Aug 2

PMID 39093354

Authors

Renae D Schmidt

Viviana E Horigian

Rui Duan

Sharleen T Traynor

Carly A Davis

Sophia T Gonzalez

Derrick J Forney

Raul Mandler

Carlos Del Rio

Lisa R Metsch

Daniel J Feaster

Affiliations

Soon will be listed here.

Abstract

To determine whether endorsement patterns of psychosocial symptoms revealed distinct subgroups, or latent classes, of people living with HIV who use substances (PLWH-SU), and to assess whether these classes demonstrated differential health outcomes over time. This study uses data from 801 PLWH-SU initially enrolled across 11 US hospitals during 2012-2014 and followed up in 2017. Latent class analysis included 28 psychosocial items. Regression analysis examined class membership as a predictor of viral suppression. Survival analysis examined class as a predictor of all-cause mortality. The selected model identified five unique classes. Individuals in classes characterized by more severe and more numerous psychosocial symptoms at baseline had lower likelihoods of viral suppression and survival. The study demonstrated the importance of considering patterns of overlapping psychosocial symptoms to identify subgroups of PLWH-SU and reveal their risks for adverse outcomes. Integration of primary, mental health, and substance use care is essential to address the needs of this population.

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