Nutrient Vitamins Enabled Metabolic Regulation of Ferroptosis Via Reactive Oxygen Species Biology

Overview

Journal Front Pharmacol

Date 2024 Aug 2

PMID 39092216

Authors

Junjie Wu

Yanting Shi

Man Zhou

Min Chen

Shuying Ji

Xingxing Liu

Mengjiao Zhou

Rui Xia

Xiaohua Zheng

Weiqi Wang

Affiliations

Soon will be listed here.

Abstract

Vitamins are dietary components necessary for cellular metabolic balance, especially redox homeostasis; deficient or excessive supply may give rise to symptoms of psychiatric disorders. Exploring the nutritional and metabolic pathways of vitamins could contribute to uncovering the underlying pathogenesis of ferroptosis-associated diseases. This mini-review aims to provide insights into vitamins closely linked to the regulation of ferroptosis from the perspective of cellular reactive oxygen species biology. The mainstream reprogramming mechanisms of ferroptosis are overviewed, focusing on unique biological processes of iron metabolism, lipid metabolism, and amino acid metabolism. Moreover, recent breakthroughs in therapeutic interventions targeting ferroptosis via fully utilizing vitamin-based pharmacological tools were overviewed, covering vitamins (B, C, E, and K). Finally, mechanism insight related to vitamin-associated nutrient signaling was provided, highlighting the pharmacological benefits of metabolically reprogramming ferroptosis-associated diseases.

Citing Articles

Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy.

Gong B, Zhang Q, Chen J, Qu Y, Luo X, Wang W Pharmaceutics. 2025; 17(2).

PMID: 40006611 PMC: 11860060. DOI: 10.3390/pharmaceutics17020244.

Mechanisms of Vitamins Inhibiting Ferroptosis.

Zhang M, Chen X, Zhang Y Antioxidants (Basel). 2025; 13(12.

PMID: 39765898 PMC: 11673384. DOI: 10.3390/antiox13121571.

Recent advances in cell membrane-coated porphyrin-based nanoscale MOFs for enhanced photodynamic therapy.

Zou Y, Wu J, Zhang Q, Chen J, Luo X, Qu Y Front Pharmacol. 2024; 15:1505212.

PMID: 39697550 PMC: 11652162. DOI: 10.3389/fphar.2024.1505212.

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology.

Zou Y, Chen J, Luo X, Qu Y, Zhou M, Xia R Front Pharmacol. 2024; 15:1481168.

PMID: 39512824 PMC: 11541831. DOI: 10.3389/fphar.2024.1481168.

References

Liang C, Zhang X, Yang M, Dong X . Recent Progress in Ferroptosis Inducers for Cancer Therapy. Adv Mater. 2019; 31(51):e1904197. DOI: 10.1002/adma.201904197. View

Koppula P, Zhang Y, Zhuang L, Gan B . Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond). 2018; 38(1):12. PMC: 5993148. DOI: 10.1186/s40880-018-0288-x. View

Bao W, Pang P, Zhou X, Hu F, Xiong W, Chen K . Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease. Cell Death Differ. 2021; 28(5):1548-1562. PMC: 8166828. DOI: 10.1038/s41418-020-00685-9. View

Fei J, Dai L, Gao F, Zhao J, Li J . Assembled Vitamin B2 Nanocrystals with Optical Waveguiding and Photosensitizing Properties for Potential Biomedical Application. Angew Chem Int Ed Engl. 2019; 58(22):7254-7258. DOI: 10.1002/anie.201900124. View

Gan H, Huang X, Luo X, Li J, Mo B, Cheng L . A Mitochondria-Targeted Ferroptosis Inducer Activated by Glutathione-Responsive Imaging and Depletion for Triple Negative Breast Cancer Theranostics. Adv Healthc Mater. 2023; 12(22):e2300220. DOI: 10.1002/adhm.202300220. View

Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K . The role of necroptosis in cancer biology and therapy. Mol Cancer. 2019; 18(1):100. PMC: 6532150. DOI: 10.1186/s12943-019-1029-8. View

Zhang C, Liu Z, Zhang Y, Ma L, Song E, Song Y . "Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis. Cell Death Dis. 2020; 11(3):183. PMC: 7070056. DOI: 10.1038/s41419-020-2384-5. View

Qin S, Wang Y, Li L, Liu J, Xiao C, Duan D . Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans. Cell Rep. 2022; 40(12):111381. DOI: 10.1016/j.celrep.2022.111381. View

Lee J, Roh J . SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer. Antioxidants (Basel). 2022; 11(12). PMC: 9774303. DOI: 10.3390/antiox11122444. View

10.

Bazinet R, Laye S . Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014; 15(12):771-85. DOI: 10.1038/nrn3820. View

11.

Peh H, Tan W, Liao W, Wong W . Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol. Pharmacol Ther. 2015; 162:152-69. DOI: 10.1016/j.pharmthera.2015.12.003. View

12.

Wang W, Jin Y, Xu Z, Liu X, Bajwa S, Khan W . Stimuli-activatable nanomedicines for chemodynamic therapy of cancer. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020; 12(4):e1614. DOI: 10.1002/wnan.1614. View

13.

Peterson C, Rodionov D, Osterman A, Peterson S . B Vitamins and Their Role in Immune Regulation and Cancer. Nutrients. 2020; 12(11). PMC: 7693142. DOI: 10.3390/nu12113380. View

14.

Wang L, Fu H, Song L, Wu Z, Yu J, Guo Q . Overcoming AZD9291 Resistance and Metastasis of NSCLC via Ferroptosis and Multitarget Interference by Nanocatalytic Sensitizer Plus AHP-DRI-12. Small. 2022; 19(4):e2204133. DOI: 10.1002/smll.202204133. View

15.

Shearer M, Okano T . Key Pathways and Regulators of Vitamin K Function and Intermediary Metabolism. Annu Rev Nutr. 2018; 38:127-151. DOI: 10.1146/annurev-nutr-082117-051741. View

16.

Liu Y, Huang P, Li Z, Xu C, Wang H, Jia B . Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway. Oxid Med Cell Longev. 2022; 2022:5361241. PMC: 9338737. DOI: 10.1155/2022/5361241. View

17.

Tang D, Kang R, Vanden Berghe T, Vandenabeele P, Kroemer G . The molecular machinery of regulated cell death. Cell Res. 2019; 29(5):347-364. PMC: 6796845. DOI: 10.1038/s41422-019-0164-5. View

18.

Mou Y, Wang J, Wu J, He D, Zhang C, Duan C . Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol. 2019; 12(1):34. PMC: 6441206. DOI: 10.1186/s13045-019-0720-y. View

19.

Peng F, Liao M, Qin R, Zhu S, Peng C, Fu L . Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Signal Transduct Target Ther. 2022; 7(1):286. PMC: 9376115. DOI: 10.1038/s41392-022-01110-y. View

20.

Stockwell B, Jiang X, Gu W . Emerging Mechanisms and Disease Relevance of Ferroptosis. Trends Cell Biol. 2020; 30(6):478-490. PMC: 7230071. DOI: 10.1016/j.tcb.2020.02.009. View