Effect of Supplementation with Extract and on Growth Performance and Intestinal Health in Broiler Chickens

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2024 Aug 2

PMID 39091388

Authors

Ximei Li

Jiawei Li

Haotian Yuan

Yan Chen

Shuaibing Li

Susu Jiang

Yingpai Zha Xi

Guohua Zhang

Jianxiong Lu

Affiliations

Soon will be listed here.

Abstract

Intestinal microbiota community is an important factor affecting the nutritional and health status of poultry, and its balance is crucial for improving the overall health of poultry. The study aimed to investigate the effect of dietary supplementation with extract (GUE), (Lac) and their combination (GL) on growth performance and intestinal health in broilers in an 84-day feeding experiment. Supplementary 0.1% GUE and 4.5×10 CFU/g Lac significantly increased average daily gain (ADG), and GL (0.1% GUE and 4.5×10 CFU/g Lac) increased ADG and average daily feed intake (ADFI), and decreased feed conversion rate (FCR) in broilers aged 29 to 84 d and 1 to 84 d. Dietary GUE, Lac and GL increased the superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity and decreased Malondialdehyde (MDA) content in the jejunum mucosa of broilers, and increased secretory IgA (sIgA) content in broilers at 84 d. Moreover, GUE, Lac and GL increased cecal microbial richness and diversity, and modulated microbial community composition. Both GUE and Lac reduced the harmful bacteria , , and at 28 d and , , and at 84 d, while Lac and GL increased beneficial bacteria and at 28 d. Compared with individual supplementation, GL markedly increased the SOD activity and the sIgA content, and reduced and . In conclusion, GUE and as feed additives benefit growth performance and intestinal health, and their combined use shows an even more positive effect in broilers.

Citing Articles

Effects of supplementation with vitamin D on growth performance, lipid metabolism and cecal microbiota in broiler chickens.

Li J, Li X, Tian J, Xu L, Chen Y, Jiang S Front Vet Sci. 2025; 12:1542637.

PMID: 39981311 PMC: 11839666. DOI: 10.3389/fvets.2025.1542637.

References

Shin N, Whon T, Bae J . Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends Biotechnol. 2015; 33(9):496-503. DOI: 10.1016/j.tibtech.2015.06.011. View

Wang Y, Liu L, Moore D, Shen X, Peek R, Acra S . An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells. Mucosal Immunol. 2016; 10(2):373-384. PMC: 5199635. DOI: 10.1038/mi.2016.57. View

Zhang L, Wu W, Lee Y, Xie J, Zhang H . Spatial Heterogeneity and Co-occurrence of Mucosal and Luminal Microbiome across Swine Intestinal Tract. Front Microbiol. 2018; 9:48. PMC: 5810300. DOI: 10.3389/fmicb.2018.00048. View

Han G, Lee J, Jin G, Park J, Choi Y, Chae B . Evaluating the association between body weight and the intestinal microbiota of weaned piglets via 16S rRNA sequencing. Appl Microbiol Biotechnol. 2017; 101(14):5903-5911. DOI: 10.1007/s00253-017-8304-7. View

Javed S, Gul F, Javed K, Bokhari H . : An Emerging Zoonotic Pathogen. Front Microbiol. 2017; 8:604. PMC: 5385324. DOI: 10.3389/fmicb.2017.00604. View

Dalloul R, Lillehoj H, Shellem T, Doerr J . Enhanced mucosal immunity against Eimeria acervulina in broilers fed a Lactobacillus-based probiotic. Poult Sci. 2003; 82(1):62-6. DOI: 10.1093/ps/82.1.62. View

Wu Y, Wu C, Che Y, Zhang T, Dai C, Nguyn A . Effects of Glycyrrhiza Polysaccharides on Chickens' Intestinal Health and Homeostasis. Front Vet Sci. 2022; 9:891429. PMC: 9134109. DOI: 10.3389/fvets.2022.891429. View

Ricke S, Lee S, Kim S, Park S, Shi Z . Prebiotics and the poultry gastrointestinal tract microbiome. Poult Sci. 2020; 99(2):670-677. PMC: 7587714. DOI: 10.1016/j.psj.2019.12.018. View

Ghareeb K, Awad W, Mohnl M, Porta R, Biarnes M, Bohm J . Evaluating the efficacy of an avian-specific probiotic to reduce the colonization of Campylobacter jejuni in broiler chickens. Poult Sci. 2012; 91(8):1825-32. DOI: 10.3382/ps.2012-02168. View

10.

Han X, Guo J, Qin Y, Huang W, You Y, Zhan J . Dietary regulation of the SIgA-gut microbiota interaction. Crit Rev Food Sci Nutr. 2022; 63(23):6379-6392. DOI: 10.1080/10408398.2022.2031097. View

11.

Wang J, Chen X, Wang W, Zhang Y, Yang Z, Jin Y . Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. J Ethnopharmacol. 2013; 147(1):114-21. PMC: 7125661. DOI: 10.1016/j.jep.2013.02.017. View

12.

Klaenhammer T, Altermann E, Pfeiler E, Buck B, Goh Y, OFlaherty S . Functional genomics of probiotic Lactobacilli. J Clin Gastroenterol. 2008; 42 Suppl 3 Pt 2:S160-2. DOI: 10.1097/MCG.0b013e31817da140. View

13.

Sugimura N, Li Q, Chu E, Lau H, Fong W, Liu W . modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis. Gut. 2021; . PMC: 9484392. DOI: 10.1136/gutjnl-2020-323951. View

14.

Shaufi M, Sieo C, Chong C, Gan H, Wan Ho Y . Deciphering chicken gut microbial dynamics based on high-throughput 16S rRNA metagenomics analyses. Gut Pathog. 2015; 7:4. PMC: 4372169. DOI: 10.1186/s13099-015-0051-7. View

15.

Peng Q, Zeng X, Zhu J, Wang S, Liu X, Hou C . Effects of dietary Lactobacillus plantarum B1 on growth performance, intestinal microbiota, and short chain fatty acid profiles in broiler chickens. Poult Sci. 2016; 95(4):893-900. DOI: 10.3382/ps/pev435. View

16.

Abo-Samaha M, Alghamdi Y, El-Shobokshy S, Albogami S, El-Maksoud E, Farrag F . Licorice Extract Supplementation Affects Antioxidant Activity, Growth-Related Genes, Lipid Metabolism, and Immune Markers in Broiler Chickens. Life (Basel). 2022; 12(6). PMC: 9225592. DOI: 10.3390/life12060914. View

17.

Wells C, van de Westerlo E, Jechorek R, Feltis B, Wilkins T, Erlandsen S . Bacteroides fragilis enterotoxin modulates epithelial permeability and bacterial internalization by HT-29 enterocytes. Gastroenterology. 1996; 110(5):1429-37. DOI: 10.1053/gast.1996.v110.pm8613048. View

18.

Zhou Q, Lan F, Li X, Yan W, Sun C, Li J . The Spatial and Temporal Characterization of Gut Microbiota in Broilers. Front Vet Sci. 2021; 8:712226. PMC: 8435590. DOI: 10.3389/fvets.2021.712226. View

19.

Rashidi N, Ghorbani M, Tatar A, Salari S . Response of broiler chickens reared at high density to dietary supplementation with licorice extract and probiotic. J Anim Physiol Anim Nutr (Berl). 2018; 103(1):100-107. DOI: 10.1111/jpn.13007. View

20.

Ngoc Lan P, Sakamoto M, Benno Y . Effects of two probiotic Lactobacillus strains on jejunal and cecal microbiota of broiler chicken under acute heat stress condition as revealed by molecular analysis of 16S rRNA genes. Microbiol Immunol. 2004; 48(12):917-29. DOI: 10.1111/j.1348-0421.2004.tb03620.x. View