Evaluation of the Intramammary Distribution of Breast Lesions Detected by MRI but Not Conventional Second-look B-mode Ultrasound Using an MRI/ultrasound Fusion Technique

Overview

Journal BMC Med Imaging

Publisher Biomed Central

Specialty Radiology

Date 2024 Aug 1

PMID 39090553

Authors

Masayuki Saito

Hirona Banno

Yukie Ito

Mirai Ido

Manami Goto

Takahito Ando

Yukako Mouri

Junko Kousaka

Kimihito Fujii

Tsuneo Imai

Shogo Nakano

Kojiro Suzuki

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to evaluate the intramammary distribution of MRI-detected mass and focus lesions that were difficult to identify with conventional B-mode ultrasound (US) alone. Consecutive patients with lesions detected with MRI but not second-look conventional B-mode US were enrolled between May 2015 and June 2023. Following an additional supine MRI examination, we performed third-look US using real-time virtual sonography (RVS), an MRI/US image fusion technique. We divided the distribution of MRI-detected mammary gland lesions as follows: center of the mammary gland versus other (superficial fascia, deep fascia, and atrophic mammary gland). We were able to detect 27 (84%) of 32 MRI-detected lesions using third-look US with RVS. Of these 27 lesions, 5 (19%) were in the center of the mammary gland and 22 (81%) were located in other areas. We were able to biopsy all 27 lesions; 8 (30%) were malignant and 19 (70%) were benign. Histopathologically, three malignant lesions were invasive ductal carcinoma (IDC; luminal A), one was IDC (luminal B), and four were ductal carcinoma in situ (low-grade). Malignant lesions were found in all areas. During this study period, 132 MRI-detected lesions were identified and 43 (33%) were located in the center of the mammary gland and 87 (64%) were in other areas. Also, we were able to detect 105 of 137 MRI-detected lesions by second-look conventional-B mode US and 38 (36%) were located in the center of the mammary gland and 67 (64%) were in other areas. In this study, 81% of the lesions identified using third-look US with RVS and 64% lesions detected by second-look conventional-B mode US were located outside the center of the mammary gland. We consider that adequate attention should be paid to the whole mammary gland when we perform third-look US using MRI/US fusion technique.

References

Aribal E, Tureli D, Kucukkaya F, Kaya H . Volume Navigation Technique for Ultrasound-Guided Biopsy of Breast Lesions Detected Only at MRI. AJR Am J Roentgenol. 2017; 208(6):1400-1409. DOI: 10.2214/AJR.16.16808. View

Brennan S . Breast magnetic resonance imaging for the interventionalist: magnetic resonance imaging-guided vacuum-assisted breast biopsy. Tech Vasc Interv Radiol. 2014; 17(1):40-8. DOI: 10.1053/j.tvir.2013.12.007. View

Fausto A, Fanizzi A, Volterrani L, Mazzei F, Calabrese C, Casella D . Feasibility, Image Quality and Clinical Evaluation of Contrast-Enhanced Breast MRI Performed in a Supine Position Compared to the Standard Prone Position. Cancers (Basel). 2020; 12(9). PMC: 7564182. DOI: 10.3390/cancers12092364. View

Uematsu T . Real-time virtual sonography (RVS)-guided vacuum-assisted breast biopsy for lesions initially detected with breast MRI. Jpn J Radiol. 2013; 31(12):826-31. DOI: 10.1007/s11604-013-0258-9. View

Kang D, Jung Y, Han S, Kim J, Kim T . Clinical Utility of Real-Time MR-Navigated Ultrasound with Supine Breast MRI for Suspicious Enhancing Lesions Not Identified on Second-Look Ultrasound. Ultrasound Med Biol. 2016; 43(2):412-420. DOI: 10.1016/j.ultrasmedbio.2016.09.016. View

Carbonaro L, Tannaphai P, Trimboli R, Verardi N, Fedeli M, Sardanelli F . Contrast enhanced breast MRI: spatial displacement from prone to supine patient's position. Preliminary results. Eur J Radiol. 2012; 81(6):e771-4. DOI: 10.1016/j.ejrad.2012.02.013. View

Watanabe R, Ando T, Osawa M, Ido M, Kousaka J, Mouri Y . Second-look US Using Real-time Virtual Sonography, a Coordinated Breast US and MRI System with Electromagnetic Tracking Technology: A Pilot Study. Ultrasound Med Biol. 2017; 43(10):2362-2371. DOI: 10.1016/j.ultrasmedbio.2017.04.024. View

Park H, Hong J . Vacuum-assisted breast biopsy for breast cancer. Gland Surg. 2014; 3(2):120-7. PMC: 4115763. DOI: 10.3978/j.issn.2227-684X.2014.02.03. View

Nakano S, Kousaka J, Fujii K, Yorozuya K, Yoshida M, Mouri Y . Impact of real-time virtual sonography, a coordinated sonography and MRI system that uses an image fusion technique, on the sonographic evaluation of MRI-detected lesions of the breast in second-look sonography. Breast Cancer Res Treat. 2012; 134(3):1179-88. DOI: 10.1007/s10549-012-2163-9. View

10.

Abe H, Schmidt R, Shah R, Shimauchi A, Kulkarni K, Sennett C . MR-directed ("Second-Look") ultrasound examination for breast lesions detected initially on MRI: MR and sonographic findings. AJR Am J Roentgenol. 2010; 194(2):370-7. DOI: 10.2214/AJR.09.2707. View

11.

Spick C, Schernthaner M, Pinker K, Kapetas P, Bernathova M, Polanec S . MR-guided vacuum-assisted breast biopsy of MRI-only lesions: a single center experience. Eur Radiol. 2016; 26(11):3908-3916. PMC: 5052307. DOI: 10.1007/s00330-016-4267-9. View

12.

Shimoda M, Kim S, Tokuda Y, Sota Y, Miyake T, Tanei T . Effect of Computer-aided Detection System Use on the Duration of MRI-guided Biopsy of the Breast. Anticancer Res. 2020; 40(11):6437-6441. DOI: 10.21873/anticanres.14665. View

13.

Noroozian M, Gombos E, Chikarmane S, Georgian-Smith D, Raza S, Denison C . Factors that impact the duration of MRI-guided core needle biopsy. AJR Am J Roentgenol. 2010; 194(2):W150-7. DOI: 10.2214/AJR.09.2366. View

14.

Komforti M, Harmon B . Educational Case: Ductal Carcinoma In Situ (DCIS). Acad Pathol. 2019; 6:2374289519888727. PMC: 6873275. DOI: 10.1177/2374289519888727. View

15.

Kucukkaya F, Aribal E, Tureli D, Altas H, Kaya H . Use of a Volume Navigation Technique for Combining Real-Time Ultrasound and Contrast-Enhanced MRI: Accuracy and Feasibility of a Novel Technique for Locating Breast Lesions. AJR Am J Roentgenol. 2015; 206(1):217-25. DOI: 10.2214/AJR.14.14101. View

16.

Satake H, Ishigaki S, Kitano M, Naganawa S . Prediction of prone-to-supine tumor displacement in the breast using patient position change: investigation with prone MRI and supine CT. Breast Cancer. 2014; 23(1):149-158. DOI: 10.1007/s12282-014-0545-z. View

17.

Hong M, Cha J, Kim H, Shin H, Chae E, Shin J . Second-look ultrasonography for MRI-detected suspicious breast lesions in patients with breast cancer. Ultrasonography. 2015; 34(2):125-32. PMC: 4372709. DOI: 10.14366/usg.14046. View

18.

Kuhl C . Current status of breast MR imaging. Part 2. Clinical applications. Radiology. 2007; 244(3):672-91. DOI: 10.1148/radiol.2443051661. View

19.

Uematsu T, Takahashi K, Nishimura S, Watanabe J, Yamasaki S, Sugino T . Real-time virtual sonography examination and biopsy for suspicious breast lesions identified on MRI alone. Eur Radiol. 2015; 26(4):1064-72. DOI: 10.1007/s00330-015-3892-z. View

20.

Burki T . Preoperative MRI in breast cancer. Lancet Oncol. 2015; 16(15):e530. DOI: 10.1016/S1470-2045(15)00372-1. View