DOMINO Trial Analysis: Evaluation of the Diet Effects on Symptoms in IBS Subtypes

Overview

Journal Therap Adv Gastroenterol

Publisher Sage Publications

Specialty Gastroenterology

Date 2024 Aug 1

PMID 39086991

Authors

Claudia Di Rosa

Karen Van den Houte

Annamaria Altomare

Michele Pier Luca Guarino

Linde Besard

Joris Arts

Philip Caenepeel

Hubert Piessevaux

Alain Vandenberghe

Cristophe Matthys

Jessica R Biesiekierski

Luc Capiau

Steven Ceulemans

Olivier Gernay

Lydia Jones

Sophie Maes

Christian Peetermans

Willem Raat

Jeroen Stubbe

Rudy Van Boxstael

Olivia Vandeput

Sophie Van Steenbergen

Lukas Van Oudenhove

Tim Vanuytsel

Mike Jones

Jan Tack

Florencia Carbone

Affiliations

Soon will be listed here.

Abstract

Background: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain related to defecation and/or associated to a change in bowel habits. According to the stool type, four different IBS subtypes can be recognized, constipation predominant (IBS-C), diarrhea predominant (IBS-D), mixed (IBS-M), and undefined (IBS-U). Patients report that their IBS symptoms are exacerbated by food. Thus, it is important to find a nutritional approach that could be effective in reducing IBS symptoms.

Objective: The present work is a analysis of the previously published DOMINO trial. It aimed to evaluate the effects of a self-instructed FODMAP-lowering diet smartphone application on symptoms and psychosocial aspects in primary care IBS stratifying the results for each IBS subtypes.

Design: analysis.

Methods: Two hundred twenty-two primary care IBS patients followed a FODMAP-lowering diet for 8 weeks with the support of a smartphone application. Two follow-up visits were scheduled after 16 and 24 weeks. IBS-Symptoms Severity Score (IBS-SSS), quality of life (QoL), and adherence and dietary satisfaction were evaluated.

Results: After 8 weeks, IBS-SSS improved in all IBS subtypes ( < 0.0001). Physician Health Questiionnaire (PHQ-15) improved only in IBS-D ( = 0.0006), whereas QoL improved both in IBS-D ( = 0.01) and IBS-M ( = 0.005).

Conclusion: This analysis showed that the app is useful in all IBS subtypes; thus, it could be used as an effective tool by both general practitioners and patients to manage symptoms in primary care.

Trial Registration: Ethical Commission University Hospital of Leuven reference number: S59482. Clinicaltrial.gov reference number: NCT04270487.

Citing Articles

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PMID: 39940411 PMC: 11820850. DOI: 10.3390/nu17030552.

Gut-Brain Axis and Psychopathology: Exploring the Impact of Diet with a Focus on the Low-FODMAP Approach.

Ribichini E, Scalese G, Mocci C, Severi C Nutrients. 2024; 16(20).

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