The Role of Deacetylase SIRT1 in Allergic Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Jul 31

PMID 39081309

Authors

Yun Lu

Xinyi Tang

Wenxin Wang

Jun Yang

Shengjun Wang

Affiliations

Soon will be listed here.

Abstract

The silent information regulator sirtuin 1 (SIRT1) protein is an NAD-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.

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