Theory of the Effect of Extracellular Potassium on Oscillations in the Pancreatic Beta-cell

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1985 Nov 1

PMID 3907728

Citations 5

Authors

T R Chay

J Keizer

Affiliations

Soon will be listed here.

Abstract

Based on the observation that potassium ions are compartmentalized near the surface of pancreatic beta-cells in mouse islets (Perez-Armendariz, E.M., I. Atwater, and E. Rojas 1985, Biophys. J. 48:741-749), we present a theoretical treatment of the effect of external potassium on oscillations in the pancreatic beta-cell. Our model includes the effects of ionic diffusion, the Ca2+-activated K+ channel, voltage-gated K+ and Ca2+ channels, and some of the effects of glucose. It is described by four ordinary differential equations. Numerical integration of these equations allows us to examine the effect of glucose, external K+, quinine, and tetraethylammonium ion (TEA) on the oscillations in membrane potential, intracellular Ca2+, and compartmentalized K+. The results are in good agreement with experiment.

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