Progress and Challenges of Understanding Cardiorenal Syndrome Type 3

Overview

Journal Rev Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Jul 30

PMID 39076878

Authors

Raquel Silva Neres-Santos

Giovana Marchini Armentano

Jessica Veronica da Silva

Carlos Alexandre Falconi

Marcela Sorelli Carneiro-Ramos

Affiliations

Soon will be listed here.

Abstract

The pathologies of the kidney and heart have instigated a large number of researchers around the world to try to better understand what the exact connectors responsible for the emergence and establishment of these diseases are. The classification of these pathologies into different types of cardiorenal syndromes (CRSs) over the last 15 years has greatly contributed to understanding pathophysiological and diagnostic aspects, as well as treatment strategies. However, with the advent of new technologies classified as "Omics", a new range of knowledge and new possibilities have opened up in order to effectively understand the intermediaries between the kidney-heart axis. The universe of micro-RNAs (miRNAs), epigenetic factors, and components present in extracellular vesicles (EVs) have been protagonists in studying different types of CRSs. Thus, the new challenge that is imposed is to select and link the large amount of information generated from the use of large-scale analysis techniques. The present review seeks to present some of the future perspectives related to understanding CRSs, with an emphasis on CRS type 3.

References

Ricci Z, Romagnoli S, Ronco C . Cardiorenal Syndrome. Crit Care Clin. 2021; 37(2):335-347. DOI: 10.1016/j.ccc.2020.11.003. View

Yan Y, Ma Z, Zhu J, Zeng M, Liu H, Dong Z . miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury. Am J Physiol Renal Physiol. 2020; 318(4):F878-F887. PMC: 7191449. DOI: 10.1152/ajprenal.00567.2019. View

Mas-Bargues C, Alique M, Barrus-Ortiz M, Borras C, Rodrigues-Diez R . Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome. Antioxidants (Basel). 2022; 11(1). PMC: 8773353. DOI: 10.3390/antiox11010078. View

Ishrat R, Ahmed M, Tazyeen S, Alam A, Farooqui A, Ali R . In Silico Integrative Approach Revealed Key MicroRNAs and Associated Target Genes in Cardiorenal Syndrome. Bioinform Biol Insights. 2021; 15:11779322211027396. PMC: 8256246. DOI: 10.1177/11779322211027396. View

Liu S . Heart-kidney interactions: mechanistic insights from animal models. Am J Physiol Renal Physiol. 2019; 316(5):F974-F985. DOI: 10.1152/ajprenal.00624.2017. View

Rawal S, Nagesh P, Coffey S, van Hout I, Galvin I, Bunton R . Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium. Cardiovasc Diabetol. 2019; 18(1):13. PMC: 6352455. DOI: 10.1186/s12933-019-0814-4. View

Du Y, Ning J . MiR-182 Promotes Ischemia/Reperfusion-Induced Acute Kidney Injury in Rat by Targeting FoxO3. Urol Int. 2021; 105(7-8):687-696. DOI: 10.1159/000515649. View

Gao L, Mei S, Zhang S, Qin Q, Li H, Liao Y . Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells. Theranostics. 2020; 10(3):1060-1073. PMC: 6956822. DOI: 10.7150/thno.37678. View

Kaneda R, Takada S, Yamashita Y, Choi Y, Nonaka-Sarukawa M, Soda M . Genome-wide histone methylation profile for heart failure. Genes Cells. 2008; 14(1):69-77. DOI: 10.1111/j.1365-2443.2008.01252.x. View

10.

Neirynck N, Vanholder R, Schepers E, Eloot S, Pletinck A, Glorieux G . An update on uremic toxins. Int Urol Nephrol. 2012; 45(1):139-50. DOI: 10.1007/s11255-012-0258-1. View

11.

Lv L, Feng Y, Wu M, Wang B, Li Z, Zhong X . Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury. Cell Death Differ. 2019; 27(1):210-226. PMC: 7206053. DOI: 10.1038/s41418-019-0349-y. View

12.

Di J, Yang M, Zhou H, Li M, Zhao J . MicroRNA-21-containing microvesicles from tubular epithelial cells promote cardiomyocyte hypertrophy. Ren Fail. 2021; 43(1):391-400. PMC: 7919913. DOI: 10.1080/0886022X.2021.1891098. View

13.

Ronco C, McCullough P, Anker S, Anand I, Aspromonte N, Bagshaw S . Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J. 2009; 31(6):703-11. PMC: 2838681. DOI: 10.1093/eurheartj/ehp507. View

14.

Zhao S, Li W, Yu W, Rao T, Li H, Ruan Y . Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys. Theranostics. 2021; 11(18):8660-8673. PMC: 8419054. DOI: 10.7150/thno.62820. View

15.

Zhan H, Huang F, Niu Q, Jiao M, Han X, Zhang K . Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets. Oxid Med Cell Longev. 2021; 2021:8889195. PMC: 8505057. DOI: 10.1155/2021/8889195. View

16.

McCurley A, Jaffe I . Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol. 2011; 350(2):256-65. PMC: 3214604. DOI: 10.1016/j.mce.2011.06.014. View

17.

Li Z, Song Y, Liu L, Hou N, An X, Zhan D . miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation. Cell Death Differ. 2015; 24(7):1205-1213. PMC: 5520159. DOI: 10.1038/cdd.2015.95. View

18.

Hebert K, Dias A, Delgado M, Franco E, Tamariz L, Steen D . Epidemiology and survival of the five stages of chronic kidney disease in a systolic heart failure population. Eur J Heart Fail. 2010; 12(8):861-5. DOI: 10.1093/eurjhf/hfq077. View

19.

Brandenburger T, Somoza A, Devaux Y, Lorenzen J . Noncoding RNAs in acute kidney injury. Kidney Int. 2018; 94(5):870-881. DOI: 10.1016/j.kint.2018.06.033. View

20.

Kolling M, Genschel C, Kaucsar T, Hubner A, Rong S, Schmitt R . Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury. Sci Rep. 2018; 8(1):3438. PMC: 5821887. DOI: 10.1038/s41598-018-21720-3. View