Prognostic Value of Serum 1,5-anhydroglucitol Levels in Patients with Acute Myocardial Infarction

Overview

Journal Rev Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Jul 30

PMID 39076658

Authors

Yijia Wang

Ruiyue Yang

Yanan Zhang

Zhe Wang

Xinyue Wang

Siming Wang

Wenduo Zhang

Xue Yu

Jun Dong

Wenxiang Chen

Fusui Ji

Affiliations

Soon will be listed here.

Abstract

Background: Diabetes mellitus is a major risk element for cardiovascular disease. In the present study we investigated whether 1,5-anhydroglucitol (1,5-AG), a new marker for glucose monitoring, can predict patient outcome following acute myocardial infarction (AMI).

Methods: A total of 270 AMI patients who underwent coronary angiography (CAG) at Beijing Hospital from March 2017 to 2020 were enrolled in this prospective cohort study. The serum 1,5-AG concentration and biochemical indicators were evaluated prior to CAG. Cox regression analysis was used to investigate the relationship between 1,5-AG levels and major adverse cardiovascular and cerebrovascular events (MACCEs), and with all-cause mortality.

Results: During the median follow-up period of 44 months, 49 MACCEs occurred and 33 patients died. The 1,5-AG level was significantly lower in the MACCEs group than in the MACCEs-free group ( = 0.001). Kaplan-Meier analysis also revealed that low 1,5-AG levels were associated with MACCEs ( 0.001) and with all-cause mortality ( = 0.001). Multivariate analysis showed that low 1,5-AG ( 8.8 g/mL) was an independent predictor of MACCEs (hazard ratio (HR) 2.000, 95% confidence interval (CI): 1.047-3.821, = 0.036). However, 1,5-AG was not a significant predictor for all-cause mortality in AMI patients ( 0.05).

Conclusions: Low 1,5-AG levels can predict MACCEs in AMI patients, but not all-cause mortality.

Clinical Trial Registration: NCT03072797.

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