Epigenetics of Cerebrovascular Diseases: an Update Review of Clinical Studies

Overview

Journal Epigenomics

Specialty Genetics

Date 2024 Jul 29

PMID 39072474

Authors

Anna Maria Ciaccio

Antonino Tuttolomondo

Affiliations

Soon will be listed here.

Abstract

Cerebrovascular diseases, especially stroke, are critical and heterogenous clinical conditions associated with high mortality and chronic disability. Genome-wide association studies reveal substantial stroke heritability, though specific genetic variants account for a minor fraction of stroke risk, suggesting an essential role for the epigenome. Epigenome-wide association studies and candidate gene approaches show that DNA methylation patterns significantly influence stroke susceptibility. Additionally, chromatin remodelers and non-coding RNA regulate gene expression in response to ischemic conditions. In this updated review, we summarized the progress of knowledge on epigenetics in the field of ischemic stroke underlying opportunities and challenges.

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