Selective Synthesis of Boron-Functionalized Indenes and Benzofulvenes by BCl-Promoted Cyclizations of -Alkynylstyrenes

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2024 Jul 29

PMID 39069746

Authors

Marcos Humanes

Ester Sans-Panades

Cintia Virumbrales

Ana Milian

Roberto Sanz

Patricia Garcia-Garcia

Manuel A Fernandez-Rodriguez

Affiliations

Soon will be listed here.

Abstract

A selective, metal-free synthesis of boron-functionalized indenes and benzofulvenes via BCl-mediated cyclization of -alkynylstyrenes is described. The method allows precise control over product formation by adjusting reaction conditions. These borylated products were utilized in diverse C-B bond derivatizations and in the total synthesis of Sulindac, a nonsteroidal anti-inflammatory drug, demonstrating the versatility and practicality of the developed methodology for synthetic applications.

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