Chimerism-Mediated Tolerance in Intestinal Transplantation

Overview

Journal Gastroenterol Clin North Am

Specialty Gastroenterology

Date 2024 Jul 27

PMID 39068003

Authors

Kevin Crosby

Katherine D Long

Jianing Fu

Affiliations

Soon will be listed here.

Abstract

In this review, the authors outlined concepts and strategies to achieve immune tolerance through inducing hematopoietic chimerism after solid organ transplantation and introduced challenges and opportunities in harnessing two-way alloresponses to improve outcomes after intestinal transplantation (ITx). Next, the authors discussed the dynamics and phenotypes of peripheral blood and intestinal graft T-cell subset chimerism and their association with outcomes. The authors also summarized studies on other types of immune cells after ITx and their potential participation in chimerism-mediated tolerance. The authors further discussed strategies and future directions to promote chimerism-associated tolerance after ITx to overcome rejection and minimize immunosuppression.

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