Does Microbiome Matter in Chronic Intestinal Failure Due to Type 1 Short Bowel Syndrome in Adults?

Overview

Journal Nutrients

Date 2024 Jul 27

PMID 39064725

Authors

Marta Ossola

Ilario Ferrocino

Irene Franciosa

Umberto Aimasso

Leila Cravero

Ambra Bonciolini

Vladimiro Cardenia

Fabio Dario Merlo

Marta Anro

Alessia Chiarotto

Clara Bosa

Luca Cocolin

Simona Bo

Affiliations

Soon will be listed here.

Abstract

The exact microbiome composition and function of patients with Short Bowel Syndrome (SBS) and Chronic Intestinal Failure (CIF) are still unknown. Patients with type I SBS-CIF (end-jejunostomy/ileostomy) are little represented in available studies. The aim of this study is to evaluate the microbiome characteristics of adult type 1 SBS-CIF patients according to their clinical features. Fecal microbiota was studied by amplicon-based sequencing and volatile organic compounds (VOCs) were assessed by solid-phase microextraction and gas chromatography-mass spectrometry. A total of 44 adult type 1 SBS-CIF patients were enrolled. At the family level, (38% of the relative frequency) and (24%) were predominant; at the genus level, (38% of the relative frequency) and (24%) were the dominant amplicon sequence variants (ASVs). Patients with increased stomal output showed higher ASVs for (Rho = +0.38; = 0.010), which was confirmed after adjusting for small bowel length (OR = 1.04; 95% CI 1.01-1.07, = 0.023). Hyperphagia was associated with higher concentrations of short-chain fatty acid (SCFA) esters, such as butanoic acid ethyl ester ( = 0.005) and hexanoic acid ethyl ester ( = 0.004). Dietary fiber intake was directly correlated with most VOCs. Hyperphagia was associated with dietary fiber, after adjusting for small bowel length (OR = 1.35; 95% CI 1.01-1.81; = 0.040). In type 1 SBS-CIF patients, a greater frequency of was associated with increased stomal outputs, while increased fiber intake and concentrations of SCFA esters were associated with hyperphagia. These results might have implications for clinical practice.

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