Coffee Consumption and Polymorphism Involvement in Type 2 Diabetes in a Romanian Population

Overview

Journal J Pers Med

Date 2024 Jul 27

PMID 39063971

Authors

Laura Claudia Popa

Simona Sorina Farcas

Nicoleta Ioana Andreescu

Affiliations

Soon will be listed here.

Abstract

Objectives: This study aims to find any significant correlations among polymorphism, coffee consumption, and T2DM.

Methods: A total of 358 people were enrolled in this study-218 diagnosed with T2DM, and 140 representing the control sample. The qPCR technique was performed, analyzing rs762551 (assay C_8881221) on the LightCycler 480 (Roche, Basel, Switzerland) with Gene Scanning software version 1.5.1 (Roche).

Results: Our first observation was that the diabetic patients were likely to consume more coffee than the non-diabetic subjects. People with the AA genotype, or the fast metabolizers, are the least common, yet they are the highest coffee consumers and present the highest glucose and cholesterol levels. Another important finding is the correlation between coffee intake and glucose level, which showed statistically significant differences between the diabetic group ( = 0.0002) and the control group ( = 0.029).

Conclusions: The main conclusion of this study is that according to genotype, caffeine levels, glucose, and cholesterol are interconnected and proportionally related, regardless of type 2 diabetes.

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