The Contemporary Role of Salvage Radical Prostatectomy in the Management of Recurrent Prostate Cancer: An Up-to-Date Review

Overview

Journal Life (Basel)

Specialty Biology

Date 2024 Jul 27

PMID 39063621

Authors

Stamatios Katsimperis

Alexandros Pinitas

Maria Zerva

Themistoklis Bellos

Ioannis Manolitsis

Georgios Feretzakis

Vassilios S Verykios

Ioannis Kyriazis

Panagiotis Neofytou

Sotirios Kapsalos

Panagiotis Deligiannis

Panagiotis Triantafyllou

Patrick Juliebo-Jones

Bhaskar Somani

Iraklis Mitsogiannis

Lazaros Tzelves

Affiliations

Soon will be listed here.

Abstract

Prostate cancer is the second most common cancer among men, with many treatment modalities available for patients, such as radical prostatectomy, external beam radiotherapy, brachytherapy, high-intensity focused ultrasound, cryotherapy, electroporation and other whole-gland or focal ablative novel techniques. Unfortunately, up to 60% of men with prostate cancer experience recurrence at 5 to 10 years. Salvage radical prostatectomy can be offered as an option in the setting of recurrence after a primary non-surgical treatment. However, the complexity of salvage radical prostatectomy is considered to be greater than that of primary surgery, making it the least popular treatment of choice. With the wide use of robotic platforms in urologic oncologic surgery, salvage radical prostatectomy has attracted attention again because, compared to past data, modern series involving salvage Robot-Assisted Radical Prostatectomy have shown promising results. In this narrative literature review, we comprehensively examined data on salvage radical prostatectomy. We investigated the correlation between the different types of primary prostate cancer therapy and the following salvage radical prostatectomy. Furthermore, we explored the concept of a robotic approach and its beneficial effect in salvage surgery. Lastly, we emphasized several promising avenues for future research in this field.

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