Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jul 27

PMID 39062987

Authors

Sara Dal Lago

Paola Brani

Giuseppe Ietto

Daniela Dalla Gasperina

Francesco Gianfagna

Cristina Giaroni

Annalisa Bosi

Francesca Drago Ferrante

Angelo Genoni

Hafza Zahira Manzoor

Andrea Ambrosini

Marco De Cicco

Corradina Dina Quartarone

Sara Khemara

Giulio Carcano

Fabrizio Maggi

Andreina Baj

Affiliations

Soon will be listed here.

Abstract

Torque Teno Virus (TTV) is a ubiquitous component of the human virome, not associated with any disease. As its load increases when the immune system is compromised, such as in kidney transplant (KT) recipients, TTV load monitoring has been proposed as a method to assess immunosuppression. In this prospective study, TTV load was measured in plasma and urine samples from 42 KT recipients, immediately before KT and in the first 150 days after it. Data obtained suggest that TTV could be a relevant marker for evaluating immune status and could be used as a guide to predict the onset of infectious complications in the follow-up of KT recipients. Since we observed no differences considering distance from transplantation, while we found a changing trend in days before viral infections, we suggest to consider changes over time in the same subjects, irrespective of time distance from transplantation.

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PMID: 39813124 PMC: 11749385. DOI: 10.1080/17520363.2025.2453416.

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