The Role of Muscarinic Acetylcholine Receptor M in Cardiovascular Diseases

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jul 27

PMID 39062802

Authors

Xinxing Liu

Yi Yu

Haiying Zhang

Min Zhang

Yan Liu

Affiliations

Soon will be listed here.

Abstract

The muscarinic acetylcholine receptor M (M-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M-mAChR to the development of multiple CVDs, in which it plays a role in cardiac protection such as anti-arrhythmia, anti-hypertrophy, and anti-fibrosis. This review summarizes M-mAChR's expression patterns, functions, and underlying mechanisms of action in CVDs, especially in ischemia/reperfusion injury, cardiac hypertrophy, and heart failure, opening up a new research direction for the treatment of CVDs.

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