Exploring the Influence of / Polymorphic Variants on Adolescent Mental Health and Response to Vitamin D Supplementation in Embryonic Hippocampal Cell Lines

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Jul 27

PMID 39062692

Authors

Giulia Gizzi

Federico Fiorani

Samuela Cataldi

Martina Mandarano

Elisa Delvecchio

Claudia Mazzeschi

Elisabetta Albi

Affiliations

Soon will be listed here.

Abstract

Several single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) have been observed in association with susceptibility to various pathologies, including autism, major depression, age-related changes in cognitive functioning, and Parkinson's and Alzheimer's diseases. This study aimed to establish the association between / polymorphic variants and anxious/depressive symptoms in nonclinical adolescents from central Italy, with the goal of identifying the risk of developing both symptoms. We found no significant difference in genotype distribution or dominant/recessive models of / polymorphic variants between subjects with anxious/depressive symptoms and controls. HN9.10e cell lines carrying the AA genotype for and the CC genotype for responded better to treatment with vitamin D3 than cell lines carrying the AG genotype for and CA genotype for . Cell lines carrying the GG genotype for and the AA genotype for did not respond at all, suggesting avenues for future studies in both the general population and individuals with mental and/or neuropsychiatric disorders. These studies suggest that the level of response to vitamin D3 administered to prevent and/or treat mental or neurological disorders could depend on the polymorphic variants of the vitamin D receptor.

References

Carlberg C, Raczyk M, Zawrotna N . Vitamin D: A master example of nutrigenomics. Redox Biol. 2023; 62:102695. PMC: 10119805. DOI: 10.1016/j.redox.2023.102695. View

Bollen S, Bass J, Fujita S, Wilkinson D, Hewison M, Atherton P . The Vitamin D/Vitamin D receptor (VDR) axis in muscle atrophy and sarcopenia. Cell Signal. 2022; 96:110355. DOI: 10.1016/j.cellsig.2022.110355. View

Lye M, Tey Y, Tor Y, Shahabudin A, Ibrahim N, Ling K . Predictors of recurrence of major depressive disorder. PLoS One. 2020; 15(3):e0230363. PMC: 7082055. DOI: 10.1371/journal.pone.0230363. View

Usategui-Martin R, De Luis-Roman D, Fernandez-Gomez J, Ruiz-Mambrilla M, Perez-Castrillon J . Vitamin D Receptor () Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis. Nutrients. 2022; 14(2). PMC: 8780067. DOI: 10.3390/nu14020360. View

Kuningas M, Mooijaart S, Jolles J, Slagboom P, Westendorp R, van Heemst D . VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging. 2007; 30(3):466-73. DOI: 10.1016/j.neurobiolaging.2007.07.001. View

Lye M, Tor Y, Tey Y, Shahabudin A, Loh S, Ibrahim N . BsmI-ApaI-TaqI TAC (BAt) Haplotype of Vitamin D Receptor Gene Is Associated with Increased Risk of Major Depressive Disorder. J Mol Neurosci. 2020; 71(5):981-990. DOI: 10.1007/s12031-020-01719-0. View

Guerini F, Bolognesi E, Chiappedi M, Mensi M, Fumagalli O, Rogantini C . Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder. Autism Res. 2020; 13(5):680-690. DOI: 10.1002/aur.2279. View

Chang S, Lee H . Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019; 60(3):237-244. DOI: 10.1016/j.pedneo.2019.04.007. View

Ceccarini M, Fittipaldi S, Ciccacci C, Granese E, Centofanti F, Ragione L . Association Between DRD2 and DRD4 Polymorphisms and Eating Disorders in an Italian Population. Front Nutr. 2022; 9:838177. PMC: 8964431. DOI: 10.3389/fnut.2022.838177. View

10.

Yang H, Wu X . The Correlation Between Vitamin D Receptor (VDR) Gene Polymorphisms and Autism: A Meta-analysis. J Mol Neurosci. 2020; 70(2):260-268. DOI: 10.1007/s12031-019-01464-z. View

11.

Iwaki M, Kanemoto Y, Sawada T, Nojiri K, Kurokawa T, Tsutsumi R . Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells. PLoS One. 2023; 18(12):e0295288. PMC: 10718451. DOI: 10.1371/journal.pone.0295288. View

12.

Cataldi S, Arcuri C, Hunot S, Mecca C, Codini M, Laurenti M . Effect of Vitamin D in HN9.10e Embryonic Hippocampal Cells and in Hippocampus from MPTP-Induced Parkinson's Disease Mouse Model. Front Cell Neurosci. 2018; 12:31. PMC: 5808335. DOI: 10.3389/fncel.2018.00031. View

13.

Saponaro F, Saba A, Zucchi R . An Update on Vitamin D Metabolism. Int J Mol Sci. 2020; 21(18). PMC: 7554947. DOI: 10.3390/ijms21186573. View

14.

Albi E, Cataldi S, Baldi E, Bucherelli C, Ferri I, Sidoni A . Vitamin D receptor expression and acid sphingomyelinase activity in prefrontal region of a learning animal model. Arch Ital Biol. 2020; 157(4):120-128. DOI: 10.12871/00039829202043. View

15.

Lehmann D, Refsum H, Warden D, Medway C, Wilcock G, Smith A . The vitamin D receptor gene is associated with Alzheimer's disease. Neurosci Lett. 2011; 504(2):79-82. DOI: 10.1016/j.neulet.2011.08.057. View

16.

Saccone D, Asani F, Bornman L . Regulation of the vitamin D receptor gene by environment, genetics and epigenetics. Gene. 2015; 561(2):171-80. DOI: 10.1016/j.gene.2015.02.024. View

17.

Conte C, Arcuri C, Cataldi S, Mecca C, Codini M, Ceccarini M . Niemann-Pick Type A Disease: Behavior of Neutral Sphingomyelinase and Vitamin D Receptor. Int J Mol Sci. 2019; 20(9). PMC: 6539364. DOI: 10.3390/ijms20092365. View

18.

Maj E, Trynda J, Maj B, Gebura K, Bogunia-Kubik K, Chodynski M . Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism. J Steroid Biochem Mol Biol. 2019; 193:105431. DOI: 10.1016/j.jsbmb.2019.105431. View

19.

Gleba J, Klopotowska D, Banach J, Turlej E, Mielko K, Gebura K . Polymorphism of VDR Gene and the Sensitivity of Human Leukemia and Lymphoma Cells to Active Forms of Vitamin D. Cancers (Basel). 2022; 14(2). PMC: 8774213. DOI: 10.3390/cancers14020387. View

20.

Wang Y, Zhu J, Deluca H . Where is the vitamin D receptor?. Arch Biochem Biophys. 2012; 523(1):123-33. DOI: 10.1016/j.abb.2012.04.001. View