Influence of R577X Polymorphism on Blood Creatine Kinase Levels Relative to Number of Sprints in Brazilian Professional Soccer Players

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2024 Jul 27

PMID 39062675

Authors

Kathleen Y de Almeida

Hirofumi Zempo

Mika Saito

Tiago Cetolin

Rodrigo Dos Santos Guimaraes

Andrea Rita Marrero

Aderbal S Aguiar Jr

Naoki Kikuchi

Affiliations

Soon will be listed here.

Abstract

This study sought to assess how post-game creatine kinase (CK) levels correlate with the number of sprints and the impact of the polymorphism on this response. This research constituted a descriptive/observational, retrospective cross-sectional study. DNA was extracted from blood samples for polymorphism genotyping. CK was measured 48 h after official matches, and the number of sprints (>19 km/h) was tracked using Global Positioning System (GPS) technology. The main cohort included 23 professional soccer players from the top tier of the Brazilian Championship. We analyzed 115 GPS + CK data sets. The replication cohort comprised 18 professional soccer players from the First Division of the Championship, had the same methodology applied, and featured a total of 90 GPS (sprints > 25.2 km/h) + CK data sets. For the main cohort, a significant positive correlation was seen between the number of sprints and the CK levels ( = 0.009). Athletes with the RR genotype had higher CK levels as more sprints were performed during the match ( = 0.017). However, the relationship was not found for X allele carriers ( > 0.05). For the replication cohort, there was a near-significant correlation between CK levels and the number of sprints ( = 0.05), and RR individuals showed a significant association ( = 0.01), whereas X allele carriers did not ( = 0.06). A greater number of sprints during matches is linked to higher CK levels, primarily among players with the RR genotype, which is potentially due to an increased presence of type II muscle fibers. These findings were replicated for both cohorts of elite Brazilian soccer players, emphasizing the importance of genetic factors in injury prevention.

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