Injectable Biomimetic Gels for Biomedical Applications

Overview

Journal Biomimetics (Basel)

Date 2024 Jul 26

PMID 39056859

Authors

Hossein Omidian

Renae L Wilson

Sumana Dey Chowdhury

Affiliations

Soon will be listed here.

Abstract

Biomimetic gels are synthetic materials designed to mimic the properties and functions of natural biological systems, such as tissues and cellular environments. This manuscript explores the advancements and future directions of injectable biomimetic gels in biomedical applications and highlights the significant potential of hydrogels in wound healing, tissue regeneration, and controlled drug delivery due to their enhanced biocompatibility, multifunctionality, and mechanical properties. Despite these advancements, challenges such as mechanical resilience, controlled degradation rates, and scalable manufacturing remain. This manuscript discusses ongoing research to optimize these properties, develop cost-effective production techniques, and integrate emerging technologies like 3D bioprinting and nanotechnology. Addressing these challenges through collaborative efforts is essential for unlocking the full potential of injectable biomimetic gels in tissue engineering and regenerative medicine.

Citing Articles

Advancements in Bone Replacement Techniques-Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ).

Bovari-Biri J, Miskei J, Kover Z, Steinerbrunner-Nagy A, Kardos K, Maroti P Cells. 2025; 14(2).

PMID: 39851573 PMC: 11763601. DOI: 10.3390/cells14020145.

Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications.

Demirci G, Goszczynska A, Sokolowska M, Zwir M, Goracy K, El Fray M Polymers (Basel). 2025; 16(24.

PMID: 39771436 PMC: 11678372. DOI: 10.3390/polym16243584.

References

Pena B, Bosi S, Aguado B, Borin D, Farnsworth N, Dobrinskikh E . Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation. ACS Appl Mater Interfaces. 2017; 9(37):31645-31656. PMC: 5672802. DOI: 10.1021/acsami.7b11438. View

Liang Y, Xu H, Li Z, Zhangji A, Guo B . Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing. Nanomicro Lett. 2022; 14(1):185. PMC: 9470803. DOI: 10.1007/s40820-022-00928-z. View

Balitaan J, Luo W, Su Y, Yu C, Wu T, Chang C . Healing Wounds Efficiently with Biomimetic Soft Matter: Injectable Self-Healing Neutral Glycol Chitosan/Dibenzaldehyde-Terminated Poly(ethylene glycol) Hydrogel with Inherent Antibacterial Properties. ACS Appl Bio Mater. 2023; 6(2):552-565. DOI: 10.1021/acsabm.2c00859. View

Li S, Li X, Xu Y, Fan C, Li Z, Zheng L . Collagen fibril-like injectable hydrogels from self-assembled nanoparticles for promoting wound healing. Bioact Mater. 2023; 32:149-163. PMC: 10563012. DOI: 10.1016/j.bioactmat.2023.09.012. View

Waduthanthri K, He Y, Montemagno C, Cetinel S . An injectable peptide hydrogel for reconstruction of the human trabecular meshwork. Acta Biomater. 2019; 100:244-254. DOI: 10.1016/j.actbio.2019.09.032. View

Bhattacharjee M, Escobar Ivirico J, Kan H, Shah S, Otsuka T, Bordett R . Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment. Proc Natl Acad Sci U S A. 2022; 119(4). PMC: 8794776. DOI: 10.1073/pnas.2120968119. View

Wang R, Liu L, He X, Xia Z, Zhao Z, Xi Z . Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties. Polymers (Basel). 2023; 15(8). PMC: 10143368. DOI: 10.3390/polym15081876. View

Liu B, Li J, Lei X, Miao S, Zhang S, Cheng P . Cell-loaded injectable gelatin/alginate/LAPONITE® nanocomposite hydrogel promotes bone healing in a critical-size rat calvarial defect model. RSC Adv. 2022; 10(43):25652-25661. PMC: 9055310. DOI: 10.1039/d0ra03040f. View

Gilarska A, Lewandowska-Lancucka J, Horak W, Nowakowska M . Collagen/chitosan/hyaluronic acid - based injectable hydrogels for tissue engineering applications - design, physicochemical and biological characterization. Colloids Surf B Biointerfaces. 2018; 170:152-162. DOI: 10.1016/j.colsurfb.2018.06.004. View

10.

Wang J, Li B, Pu X, Wang X, Cooper R, Gui Q . Injectable Multicomponent Biomimetic Gel Composed of Inter-Crosslinked Dendrimeric and Mesoporous Silica Nanoparticles Exhibits Highly Tunable Elasticity and Dual Drug Release Capacity. ACS Appl Mater Interfaces. 2020; 12(9):10202-10210. PMC: 10983814. DOI: 10.1021/acsami.0c01395. View

11.

Ghosh S, Ghosh T, Bhowmik S, Patidar M, Das A . Nucleopeptide-Coupled Injectable Bioconjugated Guanosine-Quadruplex Hydrogel with Inherent Antibacterial Activity. ACS Appl Bio Mater. 2023; 6(2):640-651. DOI: 10.1021/acsabm.2c00912. View

12.

Fu S, Ni P, Wang B, Chu B, Zheng L, Luo F . Injectable and thermo-sensitive PEG-PCL-PEG copolymer/collagen/n-HA hydrogel composite for guided bone regeneration. Biomaterials. 2012; 33(19):4801-9. DOI: 10.1016/j.biomaterials.2012.03.040. View

13.

Weiden J, Voerman D, Dolen Y, Das R, van Duffelen A, Hammink R . Injectable Biomimetic Hydrogels as Tools for Efficient T Cell Expansion and Delivery. Front Immunol. 2018; 9:2798. PMC: 6279891. DOI: 10.3389/fimmu.2018.02798. View

14.

Ma L, Su W, Ran Y, Ma X, Yi Z, Chen G . Synthesis and characterization of injectable self-healing hydrogels based on oxidized alginate-hybrid-hydroxyapatite nanoparticles and carboxymethyl chitosan. Int J Biol Macromol. 2020; 165(Pt A):1164-1174. DOI: 10.1016/j.ijbiomac.2020.10.004. View

15.

Jiang X, Zeng F, Zhang L, Yu A, Lu A . Engineered Injectable Cell-Laden Chitin/Chitosan Hydrogel with Adhesion and Biodegradability for Calvarial Defect Regeneration. ACS Appl Mater Interfaces. 2023; 15(17):20761-20773. DOI: 10.1021/acsami.3c02108. View

16.

Cheng W, Ding Z, Zheng X, Lu Q, Kong X, Zhou X . Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration. Biomater Sci. 2020; 8(9):2537-2548. PMC: 7204512. DOI: 10.1039/d0bm00104j. View

17.

Luo S, Wu J, Jia Z, Tang P, Sheng J, Xie C . An Injectable, Bifunctional Hydrogel with Photothermal Effects for Tumor Therapy and Bone Regeneration. Macromol Biosci. 2019; 19(9):e1900047. DOI: 10.1002/mabi.201900047. View

18.

Gudde A, van Velthoven M, Kouwer P, Roovers J, Guler Z . Injectable polyisocyanide hydrogel as healing supplement for connective tissue regeneration in an abdominal wound model. Biomaterials. 2023; 302:122337. DOI: 10.1016/j.biomaterials.2023.122337. View

19.

Chen X, Yan J, Jiang Y, Fan Y, Ying Z, Tan S . Platelet-Activating Biominerals Enhanced Injectable Hydrogels With Superior Bioactivity for Bone Regeneration. Front Bioeng Biotechnol. 2022; 10:826855. PMC: 8940219. DOI: 10.3389/fbioe.2022.826855. View

20.

Li X, Xu Q, Johnson M, Wang X, Lyu J, Li Y . A chondroitin sulfate based injectable hydrogel for delivery of stem cells in cartilage regeneration. Biomater Sci. 2021; 9(11):4139-4148. DOI: 10.1039/d1bm00482d. View