Development and Evaluation of Berberine-loaded Bigel for the Treatment of Hyperpigmentation on B16F10 Melanoma Cell Line

Overview

Journal Nanomedicine (Lond)

Specialty Biotechnology

Date 2024 Jul 26

PMID 39056145

Authors

Bharti Mangla

Pankaj Kumar

Zuber Ahamad

Shamama Javed

Waquar Ahsan

Geeta Aggarwal

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to optimize, develop, characterize and evaluate a topical nanobigel (BG) formulation containing Berberine (BRB) that exhibits anti-melanogenic properties. The Berberine-loaded bigel (BRB@BG) formulation was prepared by homogenously mixing the optimized hydrogel and oleogel. BRB@BG was characterized and cytotoxicity study was conducted to evaluate its effects on murine skin melanoma B16F10 cell lines. The optimized BRB@BG exhibited uniform texture with nanometric size, desirable spreadability and extrudability, suitable for topical applications. Cytotoxicity studies revealed that BRB@BG had a lower IC value (4.84 μg/ml) on B16F10 cell lines compared with drug alone. In conclusion, the developed BRB@BG formulation showed good potential as safe and effective topical treatment for hyperpigmentation.

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