Clinical and Microbial Evaluation of Mouthwash Containing and : A Randomized Controlled Non-inferiority Trial

Overview

Journal J Oral Biol Craniofac Res

Publisher Elsevier

Date 2024 Jul 26

PMID 39055999

Authors

Ram Surath Kumar

Anil V Ankola

Roopali M Sankeshwari

Vinuta Hampiholi

Sagar Jalihal

Atrey J Pai Khot

Varkey Nadakkavukaran Santhosh

Kavitha Ragu

Affiliations

Soon will be listed here.

Abstract

Objectives: (Apamarga) and (Ajwain) have been used in many clinical conditions, and it displays valuable properties as an alternative to Chlorhexidine (CHX) in the management of gingivitis. Therefore, this study aims to assess the effect of and (AA + TA) based herbal mouthwash, 0.2 % CHX, and placebo mouthwash on gingival health, plaque control and antibacterial activity against specific periodontal pathogens ( and ) using quantitative real-time PCR (RT-PCR).

Methods: This was a randomized controlled non-inferiority trial involving 108 children with plaque-induced gingivitis who were randomly assigned to three groups of 36 children each: Group A, AA + TA mouthwash; Group B, CHX mouthwash; and Group C, placebo mouthwash. Gingival index and plaque index were recorded at baseline, 7 and 21 day. RT-PCR was employed to determine the bacterial counts of each plaque sample at baseline and after 21 days.

Results: All three groups exhibited a gradual and significant reduction in both gingival and plaque scores from baseline to days 7 and 21. However, the placebo group did not demonstrate a significant difference in scores between days 7 and 21. Furthermore, a significant reduction in bacterial counts of and was observed in the groups receiving CHX and AA + TA mouthwash after 21 days of intervention compared to the placebo group.

Conclusion: AA + TA mouthwash demonstrated non-inferiority in anti-gingivitis and anti-plaque properties compared to CHX, suggesting its potential suitability as an alternative to CHX when used in conjunction with mechanical plaque control measures.

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