Gut Microbiota Differences in Five-year-old Children That Were Born Preterm with a History of Necrotizing Enterocolitis: A Pilot Trial

Overview

Journal iScience

Publisher Cell Press

Date 2024 Jul 26

PMID 39055941

Authors

Amanda Magnusson

Seyedeh Marziyeh Jabbari Shiadeh

Maryam Ardalan

Diana Swolin-Eide

Anders Elfvin

Affiliations

Soon will be listed here.

Abstract

The study explores the long-term effects of necrotizing enterocolitis (NEC) on gut microbiota in preterm infants by analyzing stool samples from 5-year-old children using shotgun metagenomic sequencing. It compares children with a history of NEC, treated surgically or medically, to preterm controls without NEC. Findings reveal persistent gut microbiota dysbiosis in NEC children, with reduced species diversity and evenness, especially in those treated surgically. The surgical NEC group had a lower Shannon index, indicating less microbial diversity. Significant differences in taxonomic profiles were observed, mainly influenced by surgical treatment. These results underscore the lasting impact of NEC and its treatment on gut microbiota, suggesting a need for strategies addressing long-term dysbiosis.

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