Can Intravenous Lorazepam Prevent Postictal Generalized EEG Suppression? A Case Report
Overview
Overview
Journal
Clin Neurophysiol Pract
Publisher
Elsevier
Specialty
Neurology
Date
2024 Jul 26
PMID
39055311
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Background: Postictal generalized electrographic suppression (PGES) may be considered an electrophysiological marker associated with an increased risk of sudden unexplained death in epilepsy (SUDEP).
Case Presentation: A case study is presented whereby a young man with focal to bilateral tonic-clonic seizures exhibited PGES after two spontaneously-aborted seizures; yet, after a third benzodiazepine-aborted seizure, PGES was absent.
Conclusion: This suggests that acutely administered benzodiazepines may offer direct anti-suppressive effects to prevent PGES, potentially reducing SUDEP risk.
References
1.
Lacuey N, Martins R, Vilella L, Hampson J, Rani M, Strohl K
. The association of serotonin reuptake inhibitors and benzodiazepines with ictal central apnea. Epilepsy Behav. 2019; 98(Pt A):73-79.
PMC: 8975169.
DOI: 10.1016/j.yebeh.2019.06.029.
View
2.
Cheah C, Yu F, Westenbroek R, Kalume F, Oakley J, Potter G
. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012; 109(36):14646-51.
PMC: 3437823.
DOI: 10.1073/pnas.1211591109.
View
3.
Rajakulendran S, Nashef L
. Postictal generalized EEG suppression and SUDEP: a review. J Clin Neurophysiol. 2015; 32(1):14-20.
DOI: 10.1097/WNP.0000000000000147.
View
4.
Lhatoo S, Faulkner H, Dembny K, Trippick K, Johnson C, Bird J
. An electroclinical case-control study of sudden unexpected death in epilepsy. Ann Neurol. 2010; 68(6):787-96.
DOI: 10.1002/ana.22101.
View
5.
Buchanan G
. Impaired CO-Induced Arousal in SIDS and SUDEP. Trends Neurosci. 2019; 42(4):242-250.
PMC: 6512334.
DOI: 10.1016/j.tins.2019.02.002.
View