Platinum-based Metal Complexes As Chloride Transporters That Trigger Apoptosis

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2024 Jul 26

PMID 39055016

Authors

Patrick Wang

Mohamed Fares

Radwa A Eladwy

Deep J Bhuyan

Xin Wu

William Lewis

Stephen J Loeb

Lauren K Macreadie

Philip A Gale

Affiliations

Soon will be listed here.

Abstract

In this paper we demonstrate that Pt(ii) complexes can function as efficient transmembrane chloride transporters. A series of Pt(ii) metal complexes with urea-appended isoquinoline ligands were synthesised and operate classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines induction of apoptosis and inhibition of intracellular ROS.

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