Mild Hyperbaric Oxygen Exposure Protects Heart During Ischemia/reperfusion and Affects Vascular Relaxation

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2024 Jul 25

PMID 39052036

Authors

Christopher Gutierrez

Magdalena Peirone

Andrea Carranza

Guillermo Di Girolamo

Patricia Bonazzola

Rocio Castilla

Affiliations

Soon will be listed here.

Abstract

Mild hyperbaric oxygen therapy (mHBOT) is an adjuvant therapy used in conditions where tissue oxygenation is reduced and is implemented using pressures less than 1.5 ATA and 100% O (instead of the classical HBOT at 1.9-3 ATA) which results in cheaper, easier to implement, and equally effective. mHBOT is offered for wellness and beauty and as an anti-aging strategy, in spite of the absence of studies on the cardiovascular system. Consequently, we investigated the impact of mHBOT on the cardiovascular system. Mechanical and energetic parameters of isolated heart submitted to ischemia/reperfusion injury and arterial contractile response from mHBOT-exposed rats were evaluated. In the heart, mHBOT increased pre-ischemic velocity of contraction and ischemic end-diastolic pressure and developed pressure and contractile economy during reperfusion. mHBOT decreased infarct size and increased the plasma nitrite levels. In the artery, mHBOT increased acetylcholine sensitivity. mHBOT protects the heart during ischemia/reperfusion and affects vascular relaxation.

References

Bergo G, Tyssebotn I . Cardiovascular effects of hyperbaric oxygen with and without addition of carbon dioxide. Eur J Appl Physiol Occup Physiol. 1999; 80(4):264-75. DOI: 10.1007/s004210050592. View

Black S, Johengen M, Ma Z, Bristow J, Soifer S . Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs. J Clin Invest. 1997; 100(6):1448-58. PMC: 508323. DOI: 10.1172/JCI119665. View

Blanchard E, Solaro R . Inhibition of the activation and troponin calcium binding of dog cardiac myofibrils by acidic pH. Circ Res. 1984; 55(3):382-91. DOI: 10.1161/01.res.55.3.382. View

Cabigas B, Su J, Hutchins W, Shi Y, Schaefer R, Recinos R . Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Cardiovasc Res. 2006; 72(1):143-51. DOI: 10.1016/j.cardiores.2006.06.031. View

Chen C, Chen W, Nong Z, Ma Y, Qiu S, Wu G . Cardioprotective Effects of Combined Therapy with Hyperbaric Oxygen and Diltiazem Pretreatment on Myocardial Ischemia-Reperfusion Injury in Rats. Cell Physiol Biochem. 2016; 38(5):2015-29. DOI: 10.1159/000445561. View

Drenjancevic I, Kibel A . Restoring vascular function with hyperbaric oxygen treatment: recovery mechanisms. J Vasc Res. 2013; 51(1):1-13. DOI: 10.1159/000355925. View

Fabiato A, Fabiato F . Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. J Physiol. 1978; 276:233-55. PMC: 1282422. DOI: 10.1113/jphysiol.1978.sp012231. View

Hachmo Y, Hadanny A, Abu Hamed R, Daniel-Kotovsky M, Catalogna M, Fishlev G . Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY). 2020; 12(22):22445-22456. PMC: 7746357. DOI: 10.18632/aging.202188. View

Hachmo Y, Hadanny A, Mendelovic S, Hillman P, Shapira E, Landau G . The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial. Aging (Albany NY). 2021; 13(22):24500-24510. PMC: 8660605. DOI: 10.18632/aging.203701. View

10.

Hadanny A, Efrati S . The Hyperoxic-Hypoxic Paradox. Biomolecules. 2020; 10(6). PMC: 7355982. DOI: 10.3390/biom10060958. View

11.

hadanny A, Meir O, Bechor Y, Fishlev G, Bergan J, Efrati S . The safety of hyperbaric oxygen treatment--retrospective analysis in 2,334 patients. Undersea Hyperb Med. 2016; 43(2):113-22. View

12.

Kentish J . The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle. J Physiol. 1986; 370:585-604. PMC: 1192698. DOI: 10.1113/jphysiol.1986.sp015952. View

13.

Kirby J, Snyder J, Schuerer D, Peters J, Bochicchio G . Essentials of Hyperbaric Oxygen Therapy: 2019 Review. Mo Med. 2019; 116(3):176-179. PMC: 6690283. View

14.

Leveque C, Mrakic Sposta S, Theunissen S, Germonpre P, Lambrechts K, Vezzoli A . Oxidative Stress Response Kinetics after 60 Minutes at Different (1.4 ATA and 2.5 ATA) Hyperbaric Hyperoxia Exposures. Int J Mol Sci. 2023; 24(15). PMC: 10418619. DOI: 10.3390/ijms241512361. View

15.

Micun Z, Dobrzynska W, Sieskiewicz M, Zawadzka I, Dmuchowska D, Wojewodzka-Zelezniakowicz M . Hyperbaric Oxygen Therapy in Ophthalmology: A Narrative Review. J Clin Med. 2024; 13(1). PMC: 10779579. DOI: 10.3390/jcm13010029. View

16.

Miskin B, Fox L, Abou-Al-Shaar H, Bin-Alamer O, Goertz A, Lipin C . Hyperbaric Oxygen Therapy for the Management of Mild and Moderate Traumatic Brain Injury: A Single-Center Experience. World Neurosurg. 2023; 176:e357-e370. DOI: 10.1016/j.wneu.2023.05.062. View

17.

Schauer A, Barthel P, Adams V, Linke A, Poitz D, Weinbrenner C . Pharmacological Pre- and Postconditioning With Levosimendan Protect H9c2 Cardiomyoblasts From Anoxia/Reoxygenation-induced Cell Death via PI3K/Akt Signaling. J Cardiovasc Pharmacol. 2021; 77(3):378-385. DOI: 10.1097/FJC.0000000000000969. View

18.

Schottlender N, Gottfried I, Ashery U . Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress. Biomolecules. 2021; 11(12). PMC: 8699286. DOI: 10.3390/biom11121827. View

19.

Semenza G . HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol. 2001; 13(2):167-71. DOI: 10.1016/s0955-0674(00)00194-0. View

20.

Sen S, Sen S . Therapeutic effects of hyperbaric oxygen: integrated review. Med Gas Res. 2021; 11(1):30-33. PMC: 8103971. DOI: 10.4103/2045-9912.310057. View