Fracture Healing Perspectives

Overview

Journal Clin Orthop Relat Res

Publisher Wolters Kluwer

Specialty Orthopedics

Date 1985 Nov 1

PMID 3905103

Citations 29

Authors

D J Simmons

Affiliations

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Abstract

This paper reviews the sequence of histomorphologic changes that occur in and around a fracture site, and discusses recent concepts about the roles of the cells and bone matrical moieties in promoting specific cell transformations during the phases of callus tissue formation and consolidation of the bony cortex. Current knowledge about the roles of autocrine, paracrine, and endocrine polypeptide growth and transforming factors lends new perspectives about this classic problem in bone physiology.

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