Mast Cell Responses in a Mouse Model of Food Allergy Are Regulated Via a ST2/IL-4 Axis

Overview

Journal Allergy

Specialty Allergy & Immunology

Date 2024 Jul 25

PMID 39049569

Authors

Saurav Ranjitkar

Dylan Krajewski

Caitlin Tedeschi

Nicole Maldonado Perez

Nathan Jordan

Kelly Gregory

Sallie S Schneider

Clinton B Mathias

Affiliations

Soon will be listed here.

Citing Articles

IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy.

Krajewski D, Ranjitkar S, Jordan N, Schneider S, Mathias C Front Immunol. 2025; 16:1526498.

PMID: 39935481 PMC: 11810977. DOI: 10.3389/fimmu.2025.1526498.

References

Chinthrajah S, Cao S, Liu C, Lyu S, Sindher S, Long A . Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy. JCI Insight. 2019; 4(22). PMC: 6948865. DOI: 10.1172/jci.insight.131347. View

Khodoun M, Tomar S, Tocker J, Wang Y, Finkelman F . Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33. J Allergy Clin Immunol. 2017; 141(1):171-179.e1. DOI: 10.1016/j.jaci.2017.02.046. View

Burton O, Darling A, Zhou J, Noval-Rivas M, Jones T, Gurish M . Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol. 2012; 6(4):740-50. PMC: 3600405. DOI: 10.1038/mi.2012.112. View

Cayrol C, Girard J . Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. Immunol Rev. 2017; 281(1):154-168. DOI: 10.1111/imr.12619. View

Galand C, Leyva-Castillo J, Yoon J, Han A, Lee M, McKenzie A . IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016; 138(5):1356-1366. PMC: 5099088. DOI: 10.1016/j.jaci.2016.03.056. View

Brandt E, Munitz A, Orekov T, Mingler M, McBride M, Finkelman F . Targeting IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin Immunol. 2008; 123(1):53-8. PMC: 4121593. DOI: 10.1016/j.jaci.2008.10.001. View

Townsend M, Fallon P, Matthews D, Jolin H, McKenzie A . T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med. 2000; 191(6):1069-76. PMC: 2193113. DOI: 10.1084/jem.191.6.1069. View

Brandt E, Ruff B, Filuta A, Chang W, Shik D, Khurana Hershey G . Thymic stromal lymphopoietin rather than IL-33 drives food allergy after epicutaneous sensitization to food allergen. J Allergy Clin Immunol. 2023; 151(6):1660-1666.e4. PMC: 10297746. DOI: 10.1016/j.jaci.2023.02.025. View

Noval Rivas M, Burton O, Oettgen H, Chatila T . IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J Allergy Clin Immunol. 2016; 138(3):801-811.e9. PMC: 5014699. DOI: 10.1016/j.jaci.2016.02.030. View

10.

Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan T . IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005; 23(5):479-90. DOI: 10.1016/j.immuni.2005.09.015. View

11.

Lohning M, Stroehmann A, Coyle A, Grogan J, Lin S, Gutierrez-Ramos J . T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci U S A. 1998; 95(12):6930-5. PMC: 22690. DOI: 10.1073/pnas.95.12.6930. View