Pseudorabies Virus Infection Increases the Permeability of the Mammalian Respiratory Barrier to Facilitate Infection

Overview

Journal mSphere

Publisher American Society for Microbiology

Specialties Microbiology
Parasitology

Date 2024 Jul 23

PMID 39041808

Authors

Dajun Zhang

Lin Lin

Jie Yang

Qingjie Lv

Mixue Wang

Lin Hua

Keshan Zhang

Huanchun Chen

Bin Wu

Zhong Peng

Affiliations

Soon will be listed here.

Abstract

Importance: Co-infections caused by viral and bacterial agents are common in both medical and veterinary medicine, but the related mechanisms are not fully understood. This study investigated the interactions between the zoonotic pathogens PRV and PM during the development of respiratory infections in both cell and mouse models, and reported the possible mechanisms which included: (i) the primary infection of PRV may induce the disruption and/or damage of mammal respiratory barrier, thereby contributing to the invasion of PM; (ii) PRV infection at early stage accelerates the transcription and/or expression of several cellular receptors that are beneficial for bacterial adherence. This study may shed a light on understanding the mechanisms on the secondary infection of PM promoted by different respiratory viruses (e.g., influenza virus and SARS-CoV-2) in both medical and veterinary medicine.

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