Recent Progress in Surface-Enhanced Raman Spectroscopy Detection of Biomarkers in Liquid Biopsy for Breast Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Jul 23

PMID 39040452

Authors

Xiaobei Liu

Yining Jia

Chao Zheng

Affiliations

Soon will be listed here.

Abstract

Breast cancer is the most commonly diagnosed cancer in women globally and a leading cause of cancer-related mortality. However, current detection methods, such as X-rays, ultrasound, CT scans, MRI, and mammography, have their limitations. Recently, with the advancements in precision medicine and technologies like artificial intelligence, liquid biopsy, specifically utilizing Surface-Enhanced Raman Spectroscopy (SERS), has emerged as a promising approach to detect breast cancer. Liquid biopsy, as a minimally invasive technique, can provide a temporal reflection of breast cancer occurrence and progression, along with a spatial representation of overall tumor information. SERS has been extensively employed for biomarker detection, owing to its numerous advantages such as high sensitivity, minimal sample requirements, strong multi-detection ability, and controllable background interference. This paper presents a comprehensive review of the latest research on the application of SERS in the detection of breast cancer biomarkers, including exosomes, circulating tumor cells (CTCs), miRNA, proteins and others. The aim of this review is to provide valuable insights into the potential of SERS technology for early breast cancer diagnosis.

Citing Articles

Advancing Breast Cancer Diagnosis: Optimization of Raman Spectroscopy for Urine-Based Early Detection.

Andras D, Cozan R, Muresan D, Moisoiu V, Crisan G, Bintintan V Biomedicines. 2025; 13(2).

PMID: 40002920 PMC: 11852463. DOI: 10.3390/biomedicines13020505.

References

Hernandez-Arteaga A, Zermeno-Nava J, Martinez-Martinez M, Hernandez-Cedillo A, Ojeda-Galvan H, Jose-Yacaman M . Determination of Salivary Sialic Acid Through Nanotechnology: A Useful Biomarker for the Screening of Breast Cancer. Arch Med Res. 2019; 50(3):105-110. DOI: 10.1016/j.arcmed.2019.05.013. View

Su X, Liu X, Xie Y, Chen M, Zheng C, Zhong H . Integrated SERS-Vertical Flow Biosensor Enabling Multiplexed Quantitative Profiling of Serological Exosomal Proteins in Patients for Accurate Breast Cancer Subtyping. ACS Nano. 2023; 17(4):4077-4088. DOI: 10.1021/acsnano.3c00449. View

Garrido-Castro A, Lin N, Polyak K . Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment. Cancer Discov. 2019; 9(2):176-198. PMC: 6387871. DOI: 10.1158/2159-8290.CD-18-1177. View

Roush S, Slack F . The let-7 family of microRNAs. Trends Cell Biol. 2008; 18(10):505-16. DOI: 10.1016/j.tcb.2008.07.007. View

Lan G, Ni K, Xu R, Lu K, Lin Z, Chan C . Nanoscale Metal-Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy. Angew Chem Int Ed Engl. 2017; 56(40):12102-12106. PMC: 5666692. DOI: 10.1002/anie.201704828. View

Harbeck N, Penault-Llorca F, Cortes J, Gnant M, Houssami N, Poortmans P . Breast cancer. Nat Rev Dis Primers. 2019; 5(1):66. DOI: 10.1038/s41572-019-0111-2. View

Chen H, Huang C, Wu Y, Sun N, Deng C . Exosome Metabolic Patterns on Aptamer-Coupled Polymorphic Carbon for Precise Detection of Early Gastric Cancer. ACS Nano. 2022; 16(8):12952-12963. DOI: 10.1021/acsnano.2c05355. View

Wang Z, Ye S, Zhang N, Liu X, Wang M . Triggerable Mutually Amplified Signal Probe Based SERS-Microfluidics Platform for the Efficient Enrichment and Quantitative Detection of miRNA. Anal Chem. 2019; 91(8):5043-5050. DOI: 10.1021/acs.analchem.8b05172. View

Gotrik M, Feagin T, Csordas A, Nakamoto M, Soh H . Advancements in Aptamer Discovery Technologies. Acc Chem Res. 2016; 49(9):1903-10. DOI: 10.1021/acs.accounts.6b00283. View

10.

Kwizera E, OConnor R, Vinduska V, Williams M, Butch E, Snyder S . Molecular Detection and Analysis of Exosomes Using Surface-Enhanced Raman Scattering Gold Nanorods and a Miniaturized Device. Theranostics. 2018; 8(10):2722-2738. PMC: 5957005. DOI: 10.7150/thno.21358. View

11.

Kang Y, Purcell E, Palacios-Rolston C, Lo T, Ramnath N, Jolly S . Isolation and Profiling of Circulating Tumor-Associated Exosomes Using Extracellular Vesicular Lipid-Protein Binding Affinity Based Microfluidic Device. Small. 2019; 15(47):e1903600. PMC: 6951813. DOI: 10.1002/smll.201903600. View

12.

Lin J, Chen R, Feng S, Pan J, Li Y, Chen G . A novel blood plasma analysis technique combining membrane electrophoresis with silver nanoparticle-based SERS spectroscopy for potential applications in noninvasive cancer detection. Nanomedicine. 2011; 7(5):655-63. DOI: 10.1016/j.nano.2011.01.012. View

13.

Dixon A, Bathany C, Tsuei M, White J, Barald K, Takayama S . Recent developments in multiplexing techniques for immunohistochemistry. Expert Rev Mol Diagn. 2015; 15(9):1171-86. PMC: 4810438. DOI: 10.1586/14737159.2015.1069182. View

14.

Liang L, Shen Y, Zhang J, Xu S, Xu W, Liang C . Identification of breast cancer through spectroscopic analysis of cell-membrane sialic acid expression. Anal Chim Acta. 2018; 1033:148-155. DOI: 10.1016/j.aca.2018.04.072. View

15.

Bardelli A, Pantel K . Liquid Biopsies, What We Do Not Know (Yet). Cancer Cell. 2017; 31(2):172-179. DOI: 10.1016/j.ccell.2017.01.002. View

16.

Gao F, Jiao F, Xia C, Zhao Y, Ying W, Xie Y . A novel strategy for facile serum exosome isolation based on specific interactions between phospholipid bilayers and TiO. Chem Sci. 2019; 10(6):1579-1588. PMC: 6369439. DOI: 10.1039/c8sc04197k. View

17.

Chen J, Wu Y, Fu C, Cao H, Tan X, Shi W . Ratiometric SERS biosensor for sensitive and reproducible detection of microRNA based on mismatched catalytic hairpin assembly. Biosens Bioelectron. 2019; 143:111619. DOI: 10.1016/j.bios.2019.111619. View

18.

Zhou T, Fan M, You R, Lu Y, Huang L, Xu Y . Fabrication of FeO/Au@ATP@Ag Nanorod sandwich structure for sensitive SERS quantitative detection of histamine. Anal Chim Acta. 2020; 1104:199-206. DOI: 10.1016/j.aca.2020.01.017. View

19.

Xu W, Zhang Y, Hou D, Shen J, Dong J, Gao Z . Quantitative SERS detection of multiple breast cancer miRNAs based on duplex specific nuclease-mediated signal amplification. Anal Methods. 2023; 15(24):2915-2924. DOI: 10.1039/d3ay00583f. View

20.

Shagin D, Rebrikov D, Kozhemyako V, Altshuler I, Shcheglov A, Zhulidov P . A novel method for SNP detection using a new duplex-specific nuclease from crab hepatopancreas. Genome Res. 2002; 12(12):1935-42. PMC: 187582. DOI: 10.1101/gr.547002. View