Systematic Review of the Mechanism and Assessment of Liver Fibrosis in Biliary Atresia

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2024 Jul 20

PMID 39033225

Authors

Jianghua Zhan

Shaowen Liu

Yu Meng

Qianhui Yang

Zhiru Wang

Shujian Zhang

Liang Ge

Li Zhao

Xiaodan Xu

Yilin Zhao

Xin Li

Xueting Wang

Affiliations

Soon will be listed here.

Abstract

Purpose: This study systematically reviewed our team's research on the mechanism and assessment of liver fibrosis in BA, summarized our experience, and discussed the future development direction.

Methods: In this study, Pubmed and Wanfang databases were searched to collect the literature published by our team on the mechanisms of liver fibrosis in BA and the assessment of liver fibrosis in BA, and the above research results were systematically reviewed.

Results: A total of 58 articles were retrieved. Among the included articles, 25 articles related to the mechanism of liver fibrosis in BA, and five articles evaluated liver fibrosis in BA. This article introduces the key pathways and molecules of liver fibrosis in BA and proposes a new grading system for liver fibrosis in BA.

Conclusions: The new BA liver fibrosis grading method is expected to assess children's conditions, guide treatment, and improve prognosis more accurately. In addition, we believe that the TGF-β1 signaling pathway is the most important in the study of liver fibrosis in BA, and at the same time, the study of EMT occurrence in BA should also be deepened to resolve the controversy on this issue.

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