A Panel Sequencing Dataset of Peripheral Blood Gene Variations in Pan-cancer

Overview

Journal Sci Data

Specialty Science

Date 2024 Jul 20

PMID 39033182

Authors

Yanxia Liu

Jie Liu

Shouwei Zhang

JinYue Wang

Zhihong Sun

Huaibo Sun

Ying Yang

Guangmin Zheng

Yu Huang

Meng Li

Zhaojun Zhang

Jingfa Xiao

Changqing Zeng

Chengming Sun

Hongzhu Qu

Xiangdong Fang

Affiliations

Soon will be listed here.

Abstract

Circulating cell-free DNA (cfDNA) in the peripheral blood is a promising biomarker for cancer diagnosis and prognosis. Somatic mutations identified in cancers have been used to detect therapeutic targets for clinical transformation and individualize drug selection, while germline variants can predict a patient's risk of developing cancer and drug sensitivity. However, no platform has been developed to analyze, calculate, integrate, and friendly visualize these pan-cancer cfDNA mutations deeply. In this work, we performed panel sequencing encompassing 1,115 cancer-related genes across 16,659 cancer patients, spanning 27 cancer types. We detected 496 germline variants in leukocytes and 11,232 somatic mutations in the cfDNA of all patients. CPGV (Cancer Peripheral blood Gene Variations), a database constructed from this dataset, is the first pan-cancer cfDNA database that encompasses somatic mutations, germline variants, and further comparative analyses of mutations across different cancer types. It bears great promise to serve as a valuable resource for cancer research.

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