Zinc Status in Cystic Fibrosis Patients; a Systematic Review and Meta-analysis

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jul 19

PMID 39027558

Authors

Mahsa Malekahmadi

Sepideh Soltani

Naseh Pahlavani

Elham Sharifi Zahabi

Hossein Kazemizadeh

Shima Hadavi

Gholamreza Mohammadi Farsani

Affiliations

Soon will be listed here.

Abstract

Background: Cystic fibrosis (CF) is an autosomal recessive hereditary disease causes concentration of secretions and this affects the lungs and digestive system. These patients are exposed to zinc (zn) deficiency. In this review, we decided to investigate the status of zn in CF patients compared to control group. Also, the clinical trials that have so far performed zinc supplementation in these patients are examined.

Method: ISI Web of Science, Scopus, PubMed/Medline, and Cochrane database were searched, up to December 2023, for studies that reported the association between zn levels of CF patients compared to a healthy control group. A random-effect model was used to compute the pooled weighted mean difference (WMD) with 95 % confidence intervals (CI). Subgroup analysis was done for region, sample and method of measurement, zinc supplementation and age.

Result: Overall, meta-analysis of 9 studies (n = 383 participants) revealed that the zn levels were significantly lower in children and adolescents with CF compared with healthy subjects (WMD = -11.97 μg/dL, 95 % CI: -22.57 to -1.37; I = 92.83 %). Meta-analysis of 8 studies (n = 320 participants) revealed that the serum and plasma level of zn was significantly lower in CF patients compared with healthy subjects (WMD = -14.31 μg/dL, 95 % CI: -25.09 to -3.53; I = 88.14 %, P-heterogeneity <0.001) While the zn level in saliva and sputum was significantly higher in CF patients.

Conclusion: CF patients have decreased zn levels in circulatory reservoirs. zn may effective for the diminish the respiratory and gastrointestinal symptoms in CF patients, further well-designed clinical trial studies is required to prove these effects.

Citing Articles

Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease.

Qin W, Nie P, Hui X, Chen F, Hu X, Shi W Front Pharmacol. 2025; 16:1537749.

PMID: 39995420 PMC: 11847805. DOI: 10.3389/fphar.2025.1537749.

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