Research Progress in the Pathogenesis of Sepsis-associated Encephalopathy

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jul 19

PMID 39027435

Authors

Yue Zhou

Lu Bai

Wenjing Tang

Weiying Yang

Lichao Sun

Affiliations

Soon will be listed here.

Abstract

Sepsis is a syndrome that causes dysfunction of multiple organs due to the host's uncontrolled response to infection and is a significant contributor to morbidity and mortality in intensive care units worldwide. Surviving patients are often left with acute brain injury and long-term cognitive impairment, known as sepsis-associated encephalopathy (SAE). In recent years, researchers have directed their focus towards the pathogenesis of SAE. However, due to the complexity of its development, there remains a lack of effective treatment measures that arise as a serious issue affecting the prognosis of sepsis patients. Further research on the possible causes of SAE aims to provide clinicians with potential therapeutic targets and help develop targeted prevention strategies. This paper aims to review recent research on the pathogenesis of SAE, in order to enhance our understanding of this syndrome.

Citing Articles

Acute hyperglycemia exacerbates neuroinflammation and cognitive impairment in sepsis-associated encephalopathy by mediating the ChREBP/HIF-1α pathway.

Yao P, Wu L, Yao H, Shen W, Hu P Eur J Med Res. 2024; 29(1):546.

PMID: 39538358 PMC: 11562611. DOI: 10.1186/s40001-024-02129-3.

References

Hou N, Dai X, Lu W, Yang H, Yu H, Liu J . Sophocarpine attenuates septic liver injury through suppression of the NLRP3 inflammasome via autophagy-mediated degradation. Exp Ther Med. 2020; 20(6):249. PMC: 7651882. DOI: 10.3892/etm.2020.9379. View

Shih C, Liao M, Hsiao T, Hii H, Shen C, Chen S . Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. PLoS One. 2016; 11(9):e0163690. PMC: 5035080. DOI: 10.1371/journal.pone.0163690. View

Visitchanakun P, Tangtanatakul P, Trithiphen O, Soonthornchai W, Wongphoom J, Tachaboon S . Plasma miR-370-3P as a Biomarker of Sepsis-Associated Encephalopathy, the Transcriptomic Profiling Analysis of Microrna-Arrays From Mouse Brains. Shock. 2019; 54(3):347-357. DOI: 10.1097/SHK.0000000000001473. View

Dixon S, Lemberg K, Lamprecht M, Skouta R, Zaitsev E, Gleason C . Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012; 149(5):1060-72. PMC: 3367386. DOI: 10.1016/j.cell.2012.03.042. View

Ito H, Hosomi S, Koyama Y, Matsumoto H, Imamura Y, Ogura H . Sepsis-Associated Encephalopathy: A Mini-Review of Inflammation in the Brain and Body. Front Aging Neurosci. 2022; 14:912866. PMC: 9195626. DOI: 10.3389/fnagi.2022.912866. View

Numan Y, Jawaid Y, Hirzallah H, Kusmic D, Megri M, Aqtash O . Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study. J Clin Med. 2018; 7(8). PMC: 6111562. DOI: 10.3390/jcm7080182. View

Terrando N, Yang T, Ryu J, Newton P, Monaco C, Feldmann M . Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2014; 20:667-75. PMC: 4398668. DOI: 10.2119/molmed.2014.00143. View

Taccone F, Su F, De Deyne C, Abdellhai A, Pierrakos C, He X . Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis. Crit Care Med. 2013; 42(2):e114-22. DOI: 10.1097/CCM.0b013e3182a641b8. View

Kikuchi D, Campos A, Qu H, Forrester S, Pagano R, Lassegue B . Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy. J Neuroinflammation. 2019; 16(1):241. PMC: 6883676. DOI: 10.1186/s12974-019-1575-4. View

10.

Baez-Pagan C, Delgado-Velez M, Lasalde-Dominicci J . Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation. J Neuroimmune Pharmacol. 2015; 10(3):468-76. PMC: 4546521. DOI: 10.1007/s11481-015-9601-5. View

11.

Singh T, OHoro J, Day C, Mandrekar J, Rabinstein A . Cefepime is Associated with Acute Encephalopathy in Critically Ill Patients: A Retrospective Case-Control Study. Neurocrit Care. 2020; 33(3):695-700. PMC: 7329265. DOI: 10.1007/s12028-020-01035-w. View

12.

Wang L, Cai J, Zhao X, Ma L, Zeng P, Zhou L . Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy. Mol Cell. 2022; 83(2):281-297.e10. DOI: 10.1016/j.molcel.2022.12.002. View

13.

Bai Y, Han Q, Dong B, Lin H, Jiang Y, Zhang X . PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression. Brain Res Bull. 2022; 184:56-67. DOI: 10.1016/j.brainresbull.2022.03.015. View

14.

Tauber S, Djukic M, Gossner J, Eiffert H, Bruck W, Nau R . Sepsis-associated encephalopathy and septic encephalitis: an update. Expert Rev Anti Infect Ther. 2020; 19(2):215-231. DOI: 10.1080/14787210.2020.1812384. View

15.

Ghaisas S, Maher J, Kanthasamy A . Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther. 2015; 158:52-62. PMC: 4747781. DOI: 10.1016/j.pharmthera.2015.11.012. View

16.

Molnar L, Fulesdi B, Nemeth N, Molnar C . Sepsis-associated encephalopathy: A review of literature. Neurol India. 2018; 66(2):352-361. DOI: 10.4103/0028-3886.227299. View

17.

Fang H, Wang Y, Deng J, Zhang H, Wu Q, He L . Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice. mSystems. 2022; 7(3):e0139921. PMC: 9239149. DOI: 10.1128/msystems.01399-21. View

18.

Li S, Lv J, Li J, Zhao Z, Guo H, Zhang Y . Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve. Neurosci Lett. 2017; 662:98-104. DOI: 10.1016/j.neulet.2017.10.008. View

19.

Ehler J, Petzold A, Wittstock M, Kolbaske S, Gloger M, Henschel J . The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study. PLoS One. 2019; 14(1):e0211184. PMC: 6345472. DOI: 10.1371/journal.pone.0211184. View

20.

Zhou R, Ying J, Qiu X, Yu L, Yue Y, Liu Q . A new cell death program regulated by toll-like receptor 9 through p38 mitogen-activated protein kinase signaling pathway in a neonatal rat model with sepsis associated encephalopathy. Chin Med J (Engl). 2022; 135(12):1474-1485. PMC: 9481440. DOI: 10.1097/CM9.0000000000002010. View