Pathogenesis and Mechanism of Uremic Vascular Calcification

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Jul 19

PMID 39026575

Authors

Yingjing Shen

Affiliations

Soon will be listed here.

Abstract

This review elucidates the modeling and mechanistic studies of vascular calcification in chronic kidney disease - mineral and bone disorder. In patients with chronic kidney disease, metabolic abnormalities in uremic toxins, including phosphate and indole sulfate, are closely associated with vascular calcification. Vitamin K, vascular circadian clock, and autophagy are also key factors involved in vascular calcification. Furthermore, communication between endothelial cells and smooth muscle cells also plays a pivotal role in the regulation of this process. Together, these factors accelerate vascular calcification progression and increase the risk of cardiovascular events. Therefore, timely intervention for vascular calcification is essential for patients with chronic kidney disease.

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