Challenges and Opportunities in Bioprocessing of Gellan Gum: A Review

Gellan gum (GG) - the microbial exopolysaccharide is increasingly being adopted into drug development, tissue engineering, and food and pharmaceutical products. In spite of the commercial importance and expanding application horizon of GG, little attention has been directed toward the exploration of novel microbial cultures, development of advanced screening protocols, strain engineering, and robust upstream or downstream processes. This comprehensive review not only attempts to summarize the existing knowledge pool on GG bioprocess but also critically assesses their inherent challenges. The process optimization design augmented with advanced machine learning modeling tools, widely adopted in other microbial bioprocesses, should be extended to GG. The unification of mechanistic insight into data-driven modeling would help to formulate optimal feeding and process control strategies.