Disparate Trajectories of Cognitive Aging Among American Indian and Alaskan Native People with and Without HIV

Overview

Journal Neuropsychology

Publisher American Psychological Association

Specialty Neurology

Date 2024 Jul 18

PMID 39023931

Authors

Micah J Savin

Desiree Byrd

Lucette Cysique

Sean Rourke

Steven P Verney

Kylie Radford

Tedd Judd

Maral Aghvinian

Cara Crook

Denise Oleas

Alex Slaughter

Richard Armenta

Donald Franklin

Thomas Marcotte

Heining Cham

Monica Rivera Mindt

Affiliations

Soon will be listed here.

Abstract

Objective: This study describes trajectories of cognitive aging among American Indian/Alaskan Native (AI/AN) adults with and without HIV and the role of immunosenescence longitudinally.

Method: We characterized trajectories of cognitive aging in a sample of 333 AI/AN and 309 non-Hispanic White (NHW) adults who were followed longitudinally for up to 20 years by the HIV Neurobehavioral Research Program (HNRP) across six U.S. research sites. We used growth curve modeling with autoregressive Lag-1 structures and heterogeneous residual variances to assess the role of ethnoracial identity and HIV grouping upon decline in trajectories of cognitive aging.

Results: HIV- AI/AN adults demonstrated earlier and steeper decline in normative trajectories of cognitive aging on tasks of processing speed, timed tasks of attention/working memory, executive function, and psychomotor speed in comparison to HIV- NHW adults. Accentuated trajectories of cognitive aging were evident in both HIV+ and HIV+ immunosuppressed groups in comparison to HIV- peers and were primarily driven by the role of immunosenescence.

Conclusions: AI/AN disparities in trajectories of cognitive aging are evident and are likely explained by the interplay of biopsychosociocultural factors, including immunosenescence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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