Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2024 Jul 18

PMID 39022832

Authors

Brett P Ransegnola

Tanyaporn Pattarabanjird

Coleen A McNamara

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is a chronic inflammatory disease whose progression is fueled by proinflammatory moieties and limited by anti-inflammatory mediators. Whereas oxidative damage and the generation of oxidation-specific epitopes that act as damage-associated molecular patterns are highly inflammatory, IgM antibodies produced by B-1 and marginal zone B cells counteract unrestricted inflammation by neutralizing and encouraging clearance of these proinflammatory signals. In this review, we focus on describing the identities of IgM-producing B cells in both mice and humans, elaborating the mechanisms underlying IgM production, and discussing the potential strategies to augment the production of atheroprotective IgM. In addition, we will discuss promising therapeutic interventions in humans to help tip the scale toward augmentation of IgM production and to provide atheroprotection.

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