The Involvement of Signaling Pathways in the Pathogenesis of Osteoarthritis: An Update

Overview

Journal J Orthop Translat

Publisher Elsevier

Specialty Orthopedics

Date 2024 Jul 18

PMID 39021400

Authors

Antonietta Fazio

Alberto Di Martino

Matteo Brunello

Francesco Traina

Maria Vittoria Marvi

Antonio Mazzotti

Cesare Faldini

Lucia Manzoli

Camilla Evangelisti

Stefano Ratti

Affiliations

Soon will be listed here.

Abstract

The Translational Potential Of This Article: The identification of key signaling pathways involved in OA development and the investigation of their signaling crosstalk could pave the way for more effective treatments and improved management of OA patients in the future.

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References

Zhu Z, Huang Y, Li J, Yi D, Liao J, Xiao J . AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes. J Orthop Translat. 2022; 38:158-166. PMC: 9668625. DOI: 10.1016/j.jot.2022.10.005. View

Courties A, Berenbaum F . Is hip osteoarthritis preventable?. Joint Bone Spine. 2019; 87(5):371-375. DOI: 10.1016/j.jbspin.2019.11.010. View

Matsushita T, Sasaki H, Takayama K, Ishida K, Matsumoto T, Kubo S . The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes. J Orthop Res. 2012; 31(4):531-7. DOI: 10.1002/jor.22268. View

Lin N, Distler A, Beyer C, Philipi-Schobinger A, Breda S, Dees C . Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis. Ann Rheum Dis. 2016; 75(11):2037-2044. DOI: 10.1136/annrheumdis-2015-208420. View

Zhou J, Chen Q, Lanske B, Fleming B, Terek R, Wei X . Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Res Ther. 2014; 16(1):R11. PMC: 3978435. DOI: 10.1186/ar4437. View

Cai T, Ye H, Jiang H, Lin C, Lou C, Wang W . Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo. Int Immunopharmacol. 2023; 115:109683. DOI: 10.1016/j.intimp.2023.109683. View

Palla A, Hilgendorf K, Yang A, Kerr J, Hinken A, Demeter J . Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging. Nat Commun. 2022; 13(1):1439. PMC: 8931095. DOI: 10.1038/s41467-022-29150-6. View

Saengsiwaritt W, Ngamtipakon P, Udomsinprasert W . Vitamin D and autophagy in knee osteoarthritis: A review. Int Immunopharmacol. 2023; 123:110712. DOI: 10.1016/j.intimp.2023.110712. View

Bahrambeigi S, Yousefi B, Rahimi M, Shafiei-Irannejad V . Metformin; an old antidiabetic drug with new potentials in bone disorders. Biomed Pharmacother. 2018; 109:1593-1601. DOI: 10.1016/j.biopha.2018.11.032. View

10.

Deng Q, Li P, Che M, Liu J, Biswas S, Ma G . Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin. Elife. 2019; 8. PMC: 6764825. DOI: 10.7554/eLife.50208. View

11.

Di Martino A, Brunello M, Rossomando V, Pederiva D, Schilardi F, Stefanini N . Aesthetic Results, Functional Outcome and Radiographic Analysis in THA by Direct Anterior, Bikini and Postero-Lateral Approach: Is It Worth the Hassle?. J Clin Med. 2023; 12(3). PMC: 9917607. DOI: 10.3390/jcm12031072. View

12.

Chan B, Fuller E, Russell A, Smith S, Smith M, Jackson M . Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis Cartilage. 2011; 19(7):874-85. DOI: 10.1016/j.joca.2011.04.014. View

13.

Loeser R, Erickson E, Long D . Mitogen-activated protein kinases as therapeutic targets in osteoarthritis. Curr Opin Rheumatol. 2008; 20(5):581-6. PMC: 2892710. DOI: 10.1097/BOR.0b013e3283090463. View

14.

Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A . Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc Natl Acad Sci U S A. 2013; 110(5):1875-80. PMC: 3562777. DOI: 10.1073/pnas.1207458110. View

15.

Tang L, Sim I, Moqbel S, Wu L . Dapansutrile ameliorated chondrocyte inflammation and osteoarthritis through suppression of MAPK signaling pathway. Hum Exp Toxicol. 2022; 41:9603271221145401. DOI: 10.1177/09603271221145401. View

16.

Callahan L, Cleveland R, Allen K, Golightly Y . Racial/Ethnic, Socioeconomic, and Geographic Disparities in the Epidemiology of Knee and Hip Osteoarthritis. Rheum Dis Clin North Am. 2021; 47(1):1-20. PMC: 8248516. DOI: 10.1016/j.rdc.2020.09.001. View

17.

Li Q, Zhao Z, Wu B, Pang Q, Cui L, Zhang L . Alteration of Bone Density, Microarchitecture, and Strength in Patients with Camurati-Engelmann Disease: Assessed by HR-pQCT. J Bone Miner Res. 2021; 37(1):78-86. DOI: 10.1002/jbmr.4436. View

18.

Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C . Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res. 2008; 24(1):12-21. PMC: 2640321. DOI: 10.1359/jbmr.080901. View

19.

Zhang Y, Pizzute T, Pei M . A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell Tissue Res. 2014; 358(3):633-49. PMC: 4234693. DOI: 10.1007/s00441-014-2010-x. View

20.

Wang J, Ma J, Gu J, Wang F, Shang X, Tao H . Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes. Mol Med Rep. 2017; 16(2):1837-1845. PMC: 5562050. DOI: 10.3892/mmr.2017.6771. View