Dysregulation of TRNA Methylation in Cancer: Mechanisms and Targeting Therapeutic Strategies

Overview

Journal Cell Death Discov

Date 2024 Jul 17

PMID 39019857

Authors

Wenbin Yuan

Rui Zhang

Hao Lyu

Shuai Xiao

Dong Guo

Qi Zhang

Declan William Ali

Marek Michalak

Xing-Zhen Chen

Cefan Zhou

Jingfeng Tang

Affiliations

Soon will be listed here.

Abstract

tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes.

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