Integrated Lactylome Characterization Reveals the Molecular Dynamics of Protein Regulation in Gastrointestinal Cancers

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2024 Jul 17

PMID 39018247

Authors

Yangmiao Duan

Hanxiang Zhan

Qin Wang

Bohao Li

Huiru Gao

Duanrui Liu

Qinchen Xu

Xin Gao

Zhenya Liu

Peng Gao

Guangwei Wei

Yunshan Wang

Affiliations

Soon will be listed here.

Abstract

Lysine lactylation (Kla) plays a vital role in several physiological processes. However, the cancer-specific modulation of Kla in gastrointestinal (GI) tumors requires systematic elucidation. Here, global lactylome profiling of cancerous and adjacent tissues is conducted from 40 patients with GI cancer and identified 11698 Kla sites. Lactylome integration revealed that Kla affects proteins involved in hallmark cancer processes, including epigenetic rewiring, metabolic perturbations, and genome instability. Moreover, the study revealed pan-cancer patterns of Kla alterations, among which 37 Kla sites are consistently upregulated in all four GI cancers and are involved in gene regulation. It is further verified that lactylation of CBX3 at K10 mediates its interaction of CBX3 with the epigenetic marker H3K9me3 and facilitates GI cancer progression. Overall, this study provides an invaluable resource for understanding the lactylome landscape in GI cancers, which may provide new paths for drug discovery for these devastating diseases.

Citing Articles

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Integrated Lactylome Characterization Reveals the Molecular Dynamics of Protein Regulation in Gastrointestinal Cancers.

Duan Y, Zhan H, Wang Q, Li B, Gao H, Liu D Adv Sci (Weinh). 2024; 11(35):e2400227.

PMID: 39018247 PMC: 11425215. DOI: 10.1002/advs.202400227.

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