[Value of Calprotectin S100 A8/A9 in Predicting the Severity of Pneumonia in Children]

Overview

Journal Zhongguo Dang Dai Er Ke Za Zhi

Specialty Pediatrics

Date 2024 Jul 17

PMID 39014948

Authors

Pei Zhou

Li Peng

Lu Xu

Qing-Hua Liu

Han Huang

Li-Li Zhong

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate the role of calprotectin S100 A8/A9 complex in evaluating the condition of children with severe pneumonia (SMPP).

Methods: A prospective study was conducted among 136 children with pneumonia (MPP) and 30 healthy controls. According to the severity of the condition, the children with MPP were divided into mild subgroup (40 children) and SMPP subgroup (96 children). The levels of S100 A8/A9 complex and related inflammatory factors were compared between the MPP group and the healthy control group, as well as between the two subgroups of MPP. The role of S100 A8/A9 in assessing the severity of MPP was explored.

Results: The MPP group had a significantly higher level of S100 A8/A9 than the healthy control group, with a significantly greater increase in the SMPP subgroup (<0.05). The multivariate logistic regression analysis showed that the increases in serum C reactive protein (CRP) and S100A8/A9 were closely associated with SMPP (<0.05). The receiver operating characteristic (ROC) curve analysis showed that the combined measurement of serum S100 A8/A9 and CRP had an area under the ROC curve of 0.904 in predicting SMPP, which was significantly higher than the AUC of S100 A8/A9 or CRP alone (<0.05), with a specificity of 0.718 and a sensitivity of 0.952.

Conclusions: S100 A8/A9 is closely associated with the severity of MPP, and the combination of S100 A8/A9 with CRP is more advantageous for assessing the severity of MPP in children.

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