The Causal Role Between Circulating Immune Cells and Diabetic Nephropathy: a Bidirectional Mendelian Randomization with Mediating Insights

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2024 Jul 16

PMID 39014501

Authors

Ning Shen

Shangwei Lu

Zhijuan Kong

Ying Gao

Jinxiu Hu

Shuxuan Si

Junlin Wang

Jie Li

Wei Han

Rong Wang

Zhimei Lv

Affiliations

Soon will be listed here.

Abstract

Diabetic nephropathy (DN) is a critical inflammatory condition linked to diabetes, affecting millions worldwide. This study employs Mendelian randomization (MR) to explore the causal relationship between immune cell signatures and DN, analyzing over 731 immune signatures and incorporating data from 1400 metabolites to investigate potential mediators. Despite no statistically significant influence of DN on immunophenotypes after FDR correction, some phenotypes with unadjusted low P-values warranted mention, including CD34 on Hematopoietic Stem Cell (Myeloid cell Panel), CD45 on CD33 HLA DR (Myeloid cell Panel). Furthermore, three immunophenotypes were identified to have a significant impact on DN risk: CD16CD56 on HLA DR NK (TBNK Panel), CD45 on HLA DR T cell (TBNK Panel), and CD33 HLA DR CD11b AC (Myeloid cell Panel). Our findings underscore the critical role of immune cells in DN, highlighting potential mediators and offering new insights into its underlying mechanisms.

Citing Articles

The effects of immune cell phenotypes and plasma metabolomes on diabetic foot ulcer: a Mendelian randomization study and mediation analysis.

Niu Z, Mao L, Han L, Niu J, Zhang X, Wei G Arch Dermatol Res. 2025; 317(1):460.

PMID: 39987406 DOI: 10.1007/s00403-025-03942-4.

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