Extraordinary Model Systems for Regeneration

Overview

Journal Development

Specialty Biology

Date 2024 Jul 16

PMID 39012059

Authors

Alice Accorsi

Longhua Guo

Wallace F Marshall

Mathilda T M Mommersteeg

Yu-Ichiro Nakajima

Affiliations

Soon will be listed here.

Abstract

Regeneration is the remarkable phenomenon through which an organism can regrow lost or damaged parts with fully functional replacements, including complex anatomical structures, such as limbs. In 2019, Development launched its 'Model systems for regeneration' collection, a series of articles introducing some of the most popular model organisms for studying regeneration in vivo. To expand this topic further, this Perspective conveys the voices of five expert biologists from the field of regenerative biology, each of whom showcases some less well-known, but equally extraordinary, species for studying regeneration.

References

Fujita S, Takahashi M, Kumano G, Kuranaga E, Miura M, Nakajima Y . Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle. PLoS Biol. 2023; 21(12):e3002435. PMC: 10734932. DOI: 10.1371/journal.pbio.3002435. View

Sandoval-Guzman T, Wang H, Khattak S, Schuez M, Roensch K, Nacu E . Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species. Cell Stem Cell. 2013; 14(2):174-87. DOI: 10.1016/j.stem.2013.11.007. View

Carlson B, Onusko S, Gross J . A high-density linkage map for Astyanax mexicanus using genotyping-by-sequencing technology. G3 (Bethesda). 2014; 5(2):241-51. PMC: 4321032. DOI: 10.1534/g3.114.015438. View

Peuss R, Box A, Chen S, Wang Y, Tsuchiya D, Persons J . Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish. Nat Ecol Evol. 2020; 4(10):1416-1430. PMC: 11062081. DOI: 10.1038/s41559-020-1234-2. View

Slabodnick M, Ruby J, Dunn J, Feldman J, DeRisi J, Marshall W . The kinase regulator mob1 acts as a patterning protein for stentor morphogenesis. PLoS Biol. 2014; 12(5):e1001861. PMC: 4019465. DOI: 10.1371/journal.pbio.1001861. View

Delorme S, Lungu I, Vickaryous M . Scar-free wound healing and regeneration following tail loss in the leopard gecko, Eublepharis macularius. Anat Rec (Hoboken). 2012; 295(10):1575-95. DOI: 10.1002/ar.22490. View

Ikmi A, McKinney S, Delventhal K, Gibson M . TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis. Nat Commun. 2014; 5:5486. DOI: 10.1038/ncomms6486. View

Stockdale W, Lemieux M, Killen A, Zhao J, Hu Z, Riepsaame J . Heart Regeneration in the Mexican Cavefish. Cell Rep. 2018; 25(8):1997-2007.e7. PMC: 6280125. DOI: 10.1016/j.celrep.2018.10.072. View

Pinto B, Gamble T, Smith C, Keating S, Havird J, Chiari Y . The revised reference genome of the leopard gecko (Eublepharis macularius) provides insight into the considerations of genome phasing and assembly. J Hered. 2023; 114(5):513-520. PMC: 10445513. DOI: 10.1093/jhered/esad016. View

10.

Aspiras A, Rohner N, Martineau B, Borowsky R, Tabin C . Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions. Proc Natl Acad Sci U S A. 2015; 112(31):9668-73. PMC: 4534248. DOI: 10.1073/pnas.1510802112. View

11.

OGorman M, Thakur S, Imrie G, Moran R, Choy S, Sifuentes-Romero I . Pleiotropic function of the oca2 gene underlies the evolution of sleep loss and albinism in cavefish. Curr Biol. 2021; 31(16):3694-3701.e4. DOI: 10.1016/j.cub.2021.06.077. View

12.

Gilbert E, Vickaryous M . Neural stem/progenitor cells are activated during tail regeneration in the leopard gecko (Eublepharis macularius). J Comp Neurol. 2017; 526(2):285-309. DOI: 10.1002/cne.24335. View

13.

Houliston E, Leclere L, Munro C, Copley R, Momose T . Past, present and future of Clytia hemisphaerica as a laboratory jellyfish. Curr Top Dev Biol. 2022; 147:121-151. DOI: 10.1016/bs.ctdb.2021.12.014. View

14.

Guo L, Bloom J, Sykes S, Huang E, Kashif Z, Pham E . Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos. PLoS Genet. 2021; 17(6):e1009580. PMC: 8224956. DOI: 10.1371/journal.pgen.1009580. View

15.

Fujita S, Kuranaga E, Nakajima Y . Cell proliferation controls body size growth, tentacle morphogenesis, and regeneration in hydrozoan jellyfish . PeerJ. 2019; 7:e7579. PMC: 6714968. DOI: 10.7717/peerj.7579. View

16.

Gross J, Meyer B, Perkins M . The rise of Astyanax cavefish. Dev Dyn. 2015; 244(9):1031-1038. PMC: 4508244. DOI: 10.1002/dvdy.24253. View

17.

Riddle M, Aspiras A, Gaudenz K, Peuss R, Sung J, Martineau B . Insulin resistance in cavefish as an adaptation to a nutrient-limited environment. Nature. 2018; 555(7698):647-651. PMC: 5989729. DOI: 10.1038/nature26136. View

18.

Slabodnick M, Ruby J, Reiff S, Swart E, Gosai S, Prabakaran S . The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell. Curr Biol. 2017; 27(4):569-575. PMC: 5659724. DOI: 10.1016/j.cub.2016.12.057. View

19.

Peacock H, Gilbert E, Vickaryous M . Scar-free cutaneous wound healing in the leopard gecko, Eublepharis macularius. J Anat. 2015; 227(5):596-610. PMC: 4609196. DOI: 10.1111/joa.12368. View

20.

Potts H, Stockdale W, Mommersteeg M . Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration. J Cardiovasc Dev Dis. 2021; 8(1). PMC: 7830602. DOI: 10.3390/jcdd8010004. View